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Table 3 Univariate and multivariable analysis of Sp17 tissue expression among epithelial ovarian carcinoma specimens

From: Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study

Variable Number of patientsb,
n (% expressing Sp17c) (N = 773)
Univariate Multivariablea
  ORd (95%CI) p ORd (95%CI) p
Age at Diagnosis (yrs)    0.53 2   0.68 2
 0–39 75 (34) 1.0   1.0  
 40–49 169 (29) 0.78 (0.40, 1.5)   0.91 (0.45, 1.8)  
 50–59 251 (31) 0.85 (0.45, 1.6)   1.01 (0.52, 2.0)  
 ε 60 273 (29) 0.76 (0.40, 1.4)   0.85 (0.43, 1.7)  
 Unknown b 5     
Grade    0.011 2   < 0.001 2
 1 122 (40) 1.0   1.0  
 2 211 (30) 0.57 (0.33, 0.97)   0.41 (0.23, 0.73)  
 3 420 (28) 0.50 (0.30, 0.82)   0.30 (0.17, 0.53)  
 Unknown b 20     
Stage    0.24 2   0.38 2
 I 282 (27) 1.0   1.0  
 II 91 (29) 1.1 (0.63, 2.0)   0.94 (0.51, 1.7)  
 III 262 (34) 1.4 (0.88, 2.4)   1.4 (0.78, 2.3)  
 IV 50 (31) 1.2 (0.55, 2.6)   1.2 (0.53, 2.7)  
 Unknown b 88     
Histology    0.002 1   < 0.001 1
 Serous 518 (35) 1.0   1.0  
 Mucinous adenocarcinoma 72 (16) 0.28 (0.13, 0.59)   0.18 (0.08, 0.40)  
 Endometrioid adenocarcinoma 68 (26) 0.58 (0.31, 1.1)   0.50 (0.25, 1.0)  
 Clear cell 56 (24) 0.53 (0.27, 1.03)   0.63 (0.31, 1.3)  
 Mixed/Other 59 (20) 0.38 (0.18, 0.80)   0.42 (0.19, 0.92)  
  1. Abbreviations: OR – Odds Ratio; CI – Confidence Interval
  2. 1Overall p value
  3. 2p value from trend test
  4. aThe multivariable model included all the variables listed in the table
  5. b Patients with unknown values were included in the analysis using an unknown category
  6. c% of patients with positive immunohistochemisty was estimated from logistic models that adjusted for TMA source, rather than using the simple weighted average method
  7. dOdds ratio calculated based on the regression parameter estimates in the logistic model