Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study

Table 3 Univariate and multivariable analysis of Sp17 tissue expression among epithelial ovarian carcinoma specimens

Variable	Number of patients^b, n (% expressing Sp17^c) (N = 773)	Univariate		Multivariable^a
Variable		OR^d (95%CI)	p	OR^d (95%CI)	p
Age at Diagnosis (yrs)			0.53 ²		0.68 ²
0–39	75 (34)	1.0		1.0
40–49	169 (29)	0.78 (0.40, 1.5)		0.91 (0.45, 1.8)
50–59	251 (31)	0.85 (0.45, 1.6)		1.01 (0.52, 2.0)
ε 60	273 (29)	0.76 (0.40, 1.4)		0.85 (0.43, 1.7)
Unknown ^b	5
Grade			0.011 ²		< 0.001 ²
1	122 (40)	1.0		1.0
2	211 (30)	0.57 (0.33, 0.97)		0.41 (0.23, 0.73)
3	420 (28)	0.50 (0.30, 0.82)		0.30 (0.17, 0.53)
Unknown ^b	20
Stage			0.24 ²		0.38 ²
I	282 (27)	1.0		1.0
II	91 (29)	1.1 (0.63, 2.0)		0.94 (0.51, 1.7)
III	262 (34)	1.4 (0.88, 2.4)		1.4 (0.78, 2.3)
IV	50 (31)	1.2 (0.55, 2.6)		1.2 (0.53, 2.7)
Unknown ^b	88
Histology			0.002 ¹		< 0.001 ¹
Serous	518 (35)	1.0		1.0
Mucinous adenocarcinoma	72 (16)	0.28 (0.13, 0.59)		0.18 (0.08, 0.40)
Endometrioid adenocarcinoma	68 (26)	0.58 (0.31, 1.1)		0.50 (0.25, 1.0)
Clear cell	56 (24)	0.53 (0.27, 1.03)		0.63 (0.31, 1.3)
Mixed/Other	59 (20)	0.38 (0.18, 0.80)		0.42 (0.19, 0.92)

Abbreviations: OR – Odds Ratio; CI – Confidence Interval
¹Overall p value
²p value from trend test
^aThe multivariable model included all the variables listed in the table
^b Patients with unknown values were included in the analysis using an unknown category
^c% of patients with positive immunohistochemisty was estimated from logistic models that adjusted for TMA source, rather than using the simple weighted average method
^dOdds ratio calculated based on the regression parameter estimates in the logistic model

ISSN: 1471-2407