Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study

Table 2 Descriptive table. Comparison of all colorectal cancer patients alive 30 days after the operation stratified by cancer site (colon versus rectum) and by pre-existing psychiatric history

	All colon cancer patients ^a					All rectal cancer patients ^b
	Psychiatric disorder ^c cases (N = 301)		Referents without psychiatric disorders ^c (N = 16,340)		p-value, ^d	Psychiatric disorder^c cases (N = 121)		Referents without psychiatric disorders^c (N = 8, 432)		p-value,^d
	N	%	N	%	p-value, ^d	N	%	N	%	p-value,^d
Cancer stage ^b
Low, UICC stage (I, II)	115	38.21	7220	44.19		48	39.67	3838	45.52
Advanced UICC stage (III,IV)	164	54.49	8339	51.03	0.03	63	52.07	3860	45.78	0.377
Missing information	22	7.31	781	4.78		10	8.26	734	8.70
	Mean	SD ^e	Mean	SD ^e		Mean	SD ^e	Mean	SD ^e
Age (years)	68.44	12.46	71.13	11.25	0.001	67.22	12.02	69.03	11.29	0.041
Gender
Men	107	35.55	8109	49.63		64	52.89	5157	61.16
Women	194	64.45	8231	50.37	0.001	57	47.11	3275	38.84	0.064
Socio-economic position, n (%) ^f
Quartile 1	81	26.91	3907	23.91		38	31.40	1950	23.13
Quartile 2	99	32.89	3926	24.03		31	25.62	1921	22.78
Quartile 3	67	22.26	3812	23.33		29	23.97	2070	24.55
Quartile 4	31	10.30	3841	23.51	0.001	15	12.40	2089	24.77	0.016
Missing information	23	7.64	854	5.23		8	6.61	402	4.77
Education
Primary education/elementary school	127	42.19	6322	38.69		53	43.80	3227	38.27
Short education / professional training	98	32.56	6266	38.35		43	35.54	3423	40.60
Middle long education or university	47	15.61	2475	15.15	0.19	19	15.70	1220	14.47	0.502
Missing information	29	9.63	1.277	7.82		6	4.96	562	6.67
Charlson co-morbidity index score at date of the cancer operation, number (%)
0	173	57.48	10,819	66.21		72	59.50	6093	72.26
1	56	18.60	2428	14.86		26	21.49	1109	13.15
> 1	72	23.92	3093	18.93	0.007	23	19.01	1230	14.59	0.005

^aAll colon cancer patients (cohort 2) with an operation in Denmark 2007–2013 according to The Danish Colorectal Cancer Group database, who were alive at least 30 days after operation, by a pre-existing psychiatric history
^bAll rectum cancer patients (cohort 3) with an operation in Denmark 2007–2013 according to The Danish Colorectal Cancer Group database, who were alive at least 30 days after operation, by a pre-existing psychiatric history
^cPsychiatric disorder cases = having had a history of hospital admission for at least one psychiatric diagnosis as the primary diagnosis according to ICD-10-criteria: DF20–29: primary psychotic disorders, and DF30–39: affective disorders in the time period from 10 years to 120 days prior to the colorectal cancer operation
^dPearson Chi-square test or t-test, p-value

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