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Table 4 Summary of studies of gemcitabine-docetaxel therapy in osteosarcoma

From: Combination of gemcitabine and docetaxel: a regimen overestimated in refractory metastatic osteosarcoma?

Author

Journal

Center

Year

No.

ORR

DCR

Fariba Navid [11]

Cancer

St. Jude Children’s Research Hospital

2008

10

3 (30%)

4 (40%)

Yasmin Gosiengfiao [23]

J Pediatr Hematol Oncol

Children’s Memorial Hospital

2012

4

1 (25%)

3 (75%)

Louis Rapkin [14]

Pediatr Blood Cancer

Emory University

2012

5

0

3 (60%)

Elizabeth Fox [18]

The Oncologist

MD Anderson Cancer Center

2012

14

1 (7%)

NAa

Weixiang Qi [17]

Jpn J Clin Oncol

Shanghai Jiaotong University

2012

18

1 (5.6%)

4 (22.3%)

Aina He [13]

Int J Clin Oncol

Shanghai Jiaotong University

2013

23

3 (13%)

10 (47.8%)

Wen Xi Yu [12]

Oncology Letters

Shanghai Jiaotong University

2014

21

2 (9.5%)

6 (28.5%)

Bong Sup Song [15]

Pediatr Blood Cancer

Korea Cancer Center Hospital

2014

17

2 (11.8%)

7 (41.2%)

E. Palmerini [16]

BMC Cancer

Instituto Ortopedico Rizzoli

2016

35

6 (17.1%)

20 (57.1%)

Lee JA [24]

Pediatr Blood Cancer

Korea Cancer Center Hospital

2016

53b

5 (14.3%)

10 (28.6%)

Tanaka [27]

World J Surg Oncol

Japan Clinical Oncology Group

2016

17 (134)c

0

7 (41.2%)

Takahashi [28]

Plos One

Tohoku University Hospital

2017

5 (42)d

0

4 (80%)

  1. aNA not available
  2. bResponse datas were available in 35 patients
  3. cThis study included 134 patients with bone and soft tissue sarcoma, during which 17 (12.7%) patients were diagnosed with osteosarcoma
  4. dThis study included 42 patients with bone and soft tissue sarcoma, during which 5 (11.9%) patients were diagnosed with osteosarcoma