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Table 3 Grade 3 and 4 Toxicities observed in 52 patients (174 courses) according to CTCAE 4.0

From: Combination of gemcitabine and docetaxel: a regimen overestimated in refractory metastatic osteosarcoma?

Toxicity Grade 3 Grade 4
events (%) Patients (%) events (%) Patients (%)
Blood and lymphatic system disorders
 Bone marrow hypocellular
  Neutropenia 55 (31.6) 22 (42.3) 0 0
  Thrombocytopenia 61 (35.1) 24 (46.2) 5 (2.9) 4 (7.7)
  Anemia 52 (29.9) 16 (30.8) 0 0
  Febrile neutropenia 3 (1.7) 3 (5.8) 0 0
Gastrointestinal disorders
 Nausea 2 (1.1) 2 (3.8) 0 0
 Vomiting 2 (1.1) 2 (3.8) 0 0
 Diarrhea 1 (0.6) 1 (1.9) 0 0
 Mucositis oral 1 (0.6) 1 (1.9) 0 0
Hepatic disorders
 Elevated ALT/AST 5 (2.9) 4 (7.7) 0 0
Metabolism and nutrition disorders
 Hypokalemia 2 (1.1) 2 (3.8) 0 0
 Hypocalcemia 1 (0.6) 2 (3.8) 0 0
 Hyperglycemia 4 (2.3) 2 (3.8) 0 0