Table 3 Grade 3 and 4 Toxicities observed in 52 patients (174 courses) according to CTCAE 4.0
Toxicity | Grade 3 | Grade 4 | ||
|---|---|---|---|---|
events (%) | Patients (%) | events (%) | Patients (%) | |
Blood and lymphatic system disorders | ||||
Bone marrow hypocellular | ||||
Neutropenia | 55 (31.6) | 22 (42.3) | 0 | 0 |
Thrombocytopenia | 61 (35.1) | 24 (46.2) | 5 (2.9) | 4 (7.7) |
Anemia | 52 (29.9) | 16 (30.8) | 0 | 0 |
Febrile neutropenia | 3 (1.7) | 3 (5.8) | 0 | 0 |
Gastrointestinal disorders | ||||
Nausea | 2 (1.1) | 2 (3.8) | 0 | 0 |
Vomiting | 2 (1.1) | 2 (3.8) | 0 | 0 |
Diarrhea | 1 (0.6) | 1 (1.9) | 0 | 0 |
Mucositis oral | 1 (0.6) | 1 (1.9) | 0 | 0 |
Hepatic disorders | ||||
Elevated ALT/AST | 5 (2.9) | 4 (7.7) | 0 | 0 |
Metabolism and nutrition disorders | ||||
Hypokalemia | 2 (1.1) | 2 (3.8) | 0 | 0 |
Hypocalcemia | 1 (0.6) | 2 (3.8) | 0 | 0 |
Hyperglycemia | 4 (2.3) | 2 (3.8) | 0 | 0 |