Table 3 Selected series of SBRT for primary NSCLC and/or metastatic lung tumors

Oh et al. 2012 [45]

M

50Gy/5f, 60Gy/5f, 60Gy/4f

3-y: 94.5%

3-y: 80.0%

2-y DFS: 59.7%

Binkley et al. 2015 [40]

M

25Gy/1f,

50Gy/4f

1-y: 91.3%;

2-y: 83.8%

1-y: 74.5%;

2-y: 57.8%

2-y OS: 74.7%,

Agolli et al. 2016 [42]

M

23Gy/1f

30Gy/1f

45Gy/3f

1-y: 68.8%;

2-y: 60.2%

3-y: 54.2%

2-y OS: 67.7%;

3-y OS: 50.8%

2-y PFS: 20.3%

Thibault et al. 2014 [44]

P/M

48-60Gy/4-5f

2-y: 96% (P)

2-y: 76%

Qiu et al. 2015 [43]

M

50Gy/5-10f

2-y: 30%

2-y OS 42.8%

2-y PFS 23.5%

Kinj et al. 2016 [49]

M

60Gy/3f

1-y: 79.8%

2-y: 78.2%

1-y OS: 83.8%;

2-y OS: 69.3%

Oskan et al. 2017 [50]

M

26-60Gy/1-8f

1-y OS: 84%;

2-y OS: 73%

5-y OS: 39%

Pasqualetti et al. 2017 [54]

M

24-27Gy/1f

27-42Gy/3f

Median PFS:13.4 m

Jung et al. 2015 [48]

M

40-60Gy/3-4f

1-y: 88.7%

3-y: 70.6%

3-y OS: 64%

3-y PFS: 24%

Hamamoto et al. 2012 [46]

P/M

48-60Gy/4-5f

2-y: 87% (P);

2-y: 50% (M)

Baschnagel et al. 2013 [37]

M

48-60Gy/4-5f

1-y: 97%,

2-y: 92%,

3-y: 85%

2-y: 80%

1-y OS:83%,

2-y OS: 76%,

3-y OS-: 63%

Navarria et al. 2014 [52]

M

48Gy/4f,

60Gy/8f, 60Gy/3f

1-y: 95%,

3-y: 89%.

Recurrence in 3 of 29 patients (locally and distance)

1-y OS: 84.1%,

3-y OS: 73%

Singh et al. 2014 [53]

M

50Gy/5f

1-y: 95%,

2-y: 88%,

3-y: 80%.

All 5 patients with local recurrences had CRC

Kim et al. 2009 [27]

M

39-51Gy/3f

1-y; 76.9%,

2-y: 52.7%,

3-y: 52.7%

1-y OS: 100%,

2-y OS; 75.5%,

3-y OS: 64.7%

Hof et al. 2007 [41]

M

13-30Gy/1f

1-y: 88.6%,

2-y: 73.7%,

3-y: 63.1%

3-y: 0%

1-y OS: 78.4%,

2-y OS: 65.1%,

3-y OS: 47.8%

Nagata et al. 2002 [47]

P/M

40-48Gy/4f

1-y: 100% (P);

2-y: 100% (P);

2 mtastases from colon relapsed at 6, 7 m

Takeda et al. 2011 [39]

P/M

50Gy/5f

1-y: 97% (P),

1-y: 86% (M)

2-y: 93% (P),

2-y: 82% (M)

1-y: 80%,

2-y: 72%

Okunieff et al. 2006 [17]

M

50Gy/10f

1-y: 83%

Had an unexpected number of local failures.

Yamamoto et al. 2014 [56]

P/M

45Gy/3f, 48Gy/4f, 60Gy/8f, 60Gy/15f

3-y: 78%(P),

5-y: 72% (P)

3-y: 26%,

5-y: 26%

3-y OS: 60.9%,

5-y OS: 38.1%

Helou et al. 2017 [55]

M

48-52Gy/4-5f