Table 3 Factors associated with chemotherapy-induced Dose-Limiting Neurotoxicity (DLN)
Characteristicsa | DLNs | No DLN | Univariate analysis | Multivariate analysisd | |
|---|---|---|---|---|---|
(n = 19) | (n = 26) | p value | HR [95% CI] | p value | |
Maximum handgrip strength, mean ± SD | 29.1 ± 10.3 | 28.5 ± 9.1 | 0.64 | ||
Dynapenia | 0.13 | 0.02 | |||
No | 12 (63.2) | 22 (84.6) | 1 | ||
Yes | 7 (36.8) | 4 (15.4) | 3.5 [1.3; 9.8] | ||
Age, mean ± SD | 65.9 ± 11.5 | 66.5 ± 13.1 | 0.89 | ||
ECOG PS | 0.04 | 0.03 | |||
0 | 8 (42.1) | 4 (15.4) | 1 | ||
1 or 2 | 11 (57.9) | 22 (84.6) | 0.4 [0.2; 0.9] | ||
mGPS b | 0.39 | ||||
0 | 8 (50.0) | 9 (39.1) | |||
1 | 8 (50.0) | 9 (39.1) | |||
2 | 0 (0.0) | 2 (21.7) | |||
Primary Tumor location | 0.02 | 0.01 | |||
Stomach – Biliary tract – Small Intestine | 6 (31.6) | 1 (4.2) | 3.6 [1.3; 10.0] | ||
Other location | 13 (68.4) | 23 (95.8) | 1 | ||
Stage | 0.49 | ||||
Local | 10 (52.6) | 10 (38.5) | |||
Locally advanced | 1 (5.3) | 5 (19.2) | |||
Metastatic | 8 (42.1) | 11 (42.3) | |||
BMI, mean ± SD, kg/m2 | 23.9 ± 3.4 | 22.8 ± 4.5 | 0.048 | ||
Overweight, No. (%)c | 0.02 | ||||
Yes | 9 (47.4) | 5 (19.2) | |||
No | 10 (52.6) | 21 (80.8) | |||