Fig. 2

a A composite of representative images of MCL-1 and BAX expression measured by Western blotting. Densitometry analysis relative to alpha-tubulin in SKBR3-Par, SKBR3-L, HCC1954-Par and HCC1954-L cell lines. ‘*’ indicates a significant increase (p < 0.05) in protein expression relative to the matched parental controls. b Percentage apoptosis induced by obatoclax and/or lapatinib (72 h) in SKBR3-Par and SKBR3-L cells, measured by the TUNEL assay. Error bars represent the standard deviation of triplicate independent experiments. ‘*’ indicates a p value of < 0.05 as calculated by Student’s t-test when comparing obatoclax 300 nM between SKBR3-Par and SKBR3-L cells or when comparing obatoclax (300 nM) and lapatinib (500 nM) between SKBR3-Par and SKBR3-L cells