Fig. 1

Percentage apoptosis induction measured by the TUNEL assay and percentage cell growth measured using Viacount on the Guava EasyCyte following treatment with either DMSO or lapatinib at 150 nM and 500 nM for 72 h in a) SKBR3-Par or b) SKBR3-L cells. c) Western blot for total and cleaved PARP following treatment with 150 nM lapatinib for 6, 24 and 48 h. d) fold change in cleaved PARP (relative to total PARP) as measured by densitometry relative to untreated control. Error bars represent the standard deviation of triplicate independent experiments. ‘*’ indicates a p value of < 0.05 calculated by Student’s t-test