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Fig. 3 | BMC Cancer

Fig. 3

From: Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines

Fig. 3

Potential subclonality and biclonality of cancer cell lines. a IGH and IGK/L rearranged fraction (filtered by > 30 reads) of Burkitt lymphoma and unspecified B cell lymphoma. Blue color indicates the rearrangement fraction of the dominant rearrangement, Red color indicate the rearrangement fraction of second dominant rearrangement, Yellow color indicate the third dominant rearrangement, while smaller subclonal rearrangements (≥ 4) were aggregated and labelled in grey (See also Additional file 1: Figure S2B). The subclonality of Burkitt lymphoma cell lines CA46, EB1, GA-10, NAMALWA and Hodgkin lymphomas cell line HS611.T. The RNA sequencing read counts are indicated in front of each VDJ junction nucleotide sequence. The translated CDR3 amino acids sequences are listed right after each nucleotide sequence. c. The potential bi/oligoclonality of unspecified B cell lymphoma cell line NU-DUL-1. Multiple IGLV rearrangements were detected in this cell line. The translated CDR3 amino acids sequences are listed right after each nucleotide sequence. d. Diagram shows the possible evolution path of cell lines with subclonality or biclonality. Pattern I, subclonal rearrangements derived from the dominant rearrangement through somatic hypermutations. Pattern II, multiple rearrangements evolved independently

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