The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer

Table 3 Univariate and multivariate Cox regression analyses of TILs, LMR, and clinicopathological characteristics for survival in patients with breast cancer

Variable	Disease-free survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	p	HR (95% CI)	p
Age (> 50 vs. ≤50)	0.86 (0.44–1.70)	0.673
T stage (>T1 vs. T1)	2.53 (1.10–5.83)	0.029	2.16 (0.92–5.09)	0.079
N stage (>N0 vs. N0)	2.46 (1.11–5.45)	0.026	1.70 (0.75–3.86)	0.204
Histologic grade (G3 vs. <G3)	1.25 (0.63–2.48)	0.518
Lymphovascular invasion (yes vs. no)	3.62 (1.76–7.43)	< 0.001	3.29 (1.58–6.84)	0.001
Estrogen receptor (positive vs. negative)	0.80 (0.41–1.58)	0.526
Progesterone receptor (positive vs. negative)	0.62 (0.30–1.28)	0.196	0.89 (0.42–1.87)	0.752
HER2 (positive vs. negative)	1.95 (0.96–3.96)	0.063	2.38 (1.11–5.10)	0.025
Type of operation (Mastectomy vs. BCS)	3.14 (0.96–10.27)	0.059	2.38 (0.70–8.12)	0.164
CD8 (high vs. low)	1.04 (0.53–2.05)	0.899
FOXP3 (high vs. low)	0.97(0.50–1.91)	0.937
LMR (high vs. low)	0.37(0.18–0.77)	0.008	0.43(0.20–0.90)	0.024

CI confidence interval, HER2 human epidermal growth factor receptor 2, FOXP3 forkhead box protein 3, BCS breast conserving surgery, LMR, lymphocyte/monocyte ratio

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