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Table 3 Univariate and multivariate Cox regression analyses of TILs, LMR, and clinicopathological characteristics for survival in patients with breast cancer

From: The prognostic and predictive value of tumor-infiltrating lymphocytes and hematologic parameters in patients with breast cancer

Variable Disease-free survival
Univariate analysis Multivariate analysis
HR (95% CI) p HR (95% CI) p
Age (> 50 vs. ≤50) 0.86 (0.44–1.70) 0.673   
T stage (>T1 vs. T1) 2.53 (1.10–5.83) 0.029 2.16 (0.92–5.09) 0.079
N stage (>N0 vs. N0) 2.46 (1.11–5.45) 0.026 1.70 (0.75–3.86) 0.204
Histologic grade (G3 vs. <G3) 1.25 (0.63–2.48) 0.518   
Lymphovascular invasion (yes vs. no) 3.62 (1.76–7.43) < 0.001 3.29 (1.58–6.84) 0.001
Estrogen receptor (positive vs. negative) 0.80 (0.41–1.58) 0.526   
Progesterone receptor (positive vs. negative) 0.62 (0.30–1.28) 0.196 0.89 (0.42–1.87) 0.752
HER2 (positive vs. negative) 1.95 (0.96–3.96) 0.063 2.38 (1.11–5.10) 0.025
Type of operation (Mastectomy vs. BCS) 3.14 (0.96–10.27) 0.059 2.38 (0.70–8.12) 0.164
CD8 (high vs. low) 1.04 (0.53–2.05) 0.899   
FOXP3 (high vs. low) 0.97(0.50–1.91) 0.937   
LMR (high vs. low) 0.37(0.18–0.77) 0.008 0.43(0.20–0.90) 0.024
  1. CI confidence interval, HER2 human epidermal growth factor receptor 2, FOXP3 forkhead box protein 3, BCS breast conserving surgery, LMR, lymphocyte/monocyte ratio