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Fig. 5 | BMC Cancer

Fig. 5

From: Knockdown long non-coding RNA ANRIL inhibits proliferation, migration and invasion of HepG2 cells by down-regulation of miR-191

Fig. 5

Knockdown of ANRIL affects cells migration and invasion by regulation of miR-191. The expression vectors of sh-ANRIL#1, sh-ANRIL#2 and miR-191 mimic were transfected into HepG2 cells to alter ANRIL and miR-191 expression. a Transwell assay was performed to analyze cell migration in these transfected cells. b and c The protein levels of MMP-2 and MMP-9 were detected by western blot. d Cell invasion and (e and f) the protein level of Vimentin were determined by Transwell and western blot, respectively. ANRIL: CDKN2B antisense RNA 1; miR-191: microRNA-191; MMP-2/− 9: matrix metalloproteinase-2/− 9; *P < 0.05; **P < 0.01;***P < 0.001

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