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Table 2 Univariate and multivariate survival analysis of non-pCR patients

From: Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

Factors

Disease-free survival

Univariate

Multivariate

P

P

HR (95% CI)

Age

  < 40 vs. 40–60 vs. ≥ 60

0.062

–

–

Menopausal status

 Pre vs. Post

0.150

–

–

Initial tumor status

 T2 vs. T3 vs. T4

0.104

–

–

Residual tumor size

  ≤ 2 cm vs. 2-5 cm vs. > 5 cm

< 0.001

NS

–

Residual involved nodes

 0 vs. 1–3 vs. ≥4

< 0.001

< 0.001

1.000

  

1.409 (0.604–3.289)

  

4.124 (1.948–8.732)

Vascular invasion

 Negative vs. Positive

0.035

NS

–

Grade

 I - II vs. III

0.322

–

–

Ki-67

  < 20% vs. ≥ 20%

0.001

0.018

1.909 (1.117–3.262)

sMMP-9 at baseline

 Linear

0.226

–

 

sMMP-9 at surgery

 Linear

0.008

NS

–

sMMP-9 change

 Linear

0.019

NS

–

hMMP-9 in residual tumor

 - vs. + vs. ++

< 0.001

0.004

1.000

  

2.637 (1.341–5.183)

  

2.832 (1.348–5.950)

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