Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria

Table 2 Mutations in breast cancer risk genes and number of positive diagnostic criteria for gene testing

Mutated gene	Number of diagnostic criteria
	0	1	2	3	Total
BRCA1	3	18	11	2	34
BRCA2	2	7	3	1	13
CHEK2	1	1	0	0	2
NBN	0	1	0	0	1
RAD51C	0	2	1	0	3
RAD51D	1	0	0	0	1
PALB2	2	0	0	0	2
ATM	1	0	0	0	2
Overall	10	29	15	3	57

Each column delineates the number (0–3) of fulfilled diagnostic criteria for gene testing (0–3) for each of the risk-genes. One point was given each for diagnosis before age 35 years, for bi- or contralateral breast cancer/ ovarian cancer and for family history. Ten women out of 57 (17.5%) did not fulfill any of these criteria and would thus otherwise go untested

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