From: Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer
Genotype | Age | Sex | Helicobacter pylori infection. | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤60 | >60 | Male | Female | Positive | Negative | |||||||||||||
Ca/Co | OR (95% CI) | P | Ca/Co | OR (95% CI)a | P | Ca/Co | OR (95% CI)a | P | Ca/Co | OR (95% CI)a | P | Ca/Co | OR (95% CI)a | P | Ca/Co | OR (95% CI)a | P | |
rs10074991 | ||||||||||||||||||
AA | 33/45 | Reference | 71/83 | Reference | 69/62 | Reference | 35/36 | Reference | 52/57 | Reference | 52/71 | Reference | ||||||
AG | 90/90 | 1.31(0.76,2.25) | 0.331 | 165/171 | 1.10(0.75,1.62) | 0.630 | 197/193 | 1.35(0.93,1.95) | 0.117 | 58/68 | 0.77(0.42,1.41) | 0.399 | 142/139 | 1.12(0.72,1.75) | 0.613 | 113/122 | 1.26(0.81,1.96) | 0.302 |
GG | 45/32 | 1.93(1.00,3.73) | 0.050 | 77/69 | 1.20(0.76,1.91) | 0.436 | 88/74 | 1.51(0.97,2.37) | 0.070 | 34/27 | 1.27(0.63,2.58) | 0.503 | 68/45 | 1.68(0.98,2.88) | 0.060 | 54/56 | 1.31(0.77,2.22) | 0.318 |
AG/GG | 135/122 | 1.46(0.87,2.45) | 0.154 | 242/240 | 1.15(0.80,1.66) | 0.461 | 285/267 | 1.40(0.98,1.99) | 0.067 | 92/95 | 0.91(0.52,1.59) | 0.734 | 210/184 | 1.26(0.82,1.93) | 0.292 | 167/178 | 1.27(0.84,1.94) | 0.255 |
Additive model | 1.40(1.01,1.93) | 0.043 | 1.12(0.89,1.41) | 0.332 | 1.25(1.01,1.56) | 0.046 | 1.10(0.77,1.55) | 0.611 | 1.30(0.99,1.69) | 0.057 | 1.14(0.88,1.48) | 0.313 | ||||||
rs13361707 | ||||||||||||||||||
TT | 33/46 | Reference | 70/83 | Reference | 68/93 | Reference | 36/35 | Reference | 51/58 | Reference | 52/71 | Reference | ||||||
TC | 90/89 | 1.35(0.79,2.33) | 0.273 | 166/171 | 1.12(0.76,1.65) | 0.563 | 198/192 | 1.40(0.96,2.03) | 0.080 | 58/68 | 0.77(0.42,1.41) | 0.399 | 143/138 | 1.18(0.76,1.84) | 0.465 | 113/122 | 1.26(0.81,1.96) | 0.302 |
CC | 45/32 | 2.00(1.04,3.84) | 0.039 | 77/69 | 1.22(0.77,1.94) | 0.402 | 88/74 | 1.56(1.00,2.44) | 0.052 | 34/27 | 1.27(0.63,2.58) | 0.503 | 68/45 | 1.75(1.02,3.00) | 0.042 | 54/56 | 1.31(0.77,2.22) | 0.318 |
TC/CC | 135/121 | 1.51(0.90,2.53) | 0.119 | 242/240 | 1.17(0.81,1.69) | 0.408 | 286/266 | 1.44(1.01,2.06) | 0.044 | 92/95 | 0.91(0.52,1.59) | 0.734 | 211/183 | 1.32(0.86,2.03) | 0.200 | 167/178 | 1.27(0.84,1.94) | 0.255 |
Additive model | 1.41(1.02,1.95) | 0.036 | 1.13(0.90,1.42) | 0.305 | 1.27(1.02,1.58) | 0.034 | 1.10(0.77,1.55) | 0.611 | 1.32(1.01,1.73) | 0.041 | 1.14(0.88,1.48) | 0.313 | ||||||
rs154268 | ||||||||||||||||||
TT | 92/106 | Reference | 179/191 | Reference | 195/213 | Reference | 76/84 | Reference | 151/146 | Reference | 120/151 | Reference | ||||||
TC | 64/56 | 1.32(0.83,2.10) | 0.241 | 115/120 | 1.03(0.74,1.44) | 0.844 | 140/134 | 0.81(0.60,1.10) | 0.357 | 39/42 | 0.95(0.55,1.65) | 0.866 | 91/86 | 1.03(0.71,1.49) | 0.891 | 88/90 | 1.21(0.83,1.78) | 0.315 |
CC | 12/5 | 2.77(0.92,8.33) | 0.069 | 19/12 | 1.63(0.76,3.51) | 0.210 | 19/12 | 1,73(0.81,3.67) | 0.153 | 12/5 | 2.44(0.82,7.29) | 0.111 | 20/9 | 2.16(0.95,4.91) | 0.068 | 11/8 | 1.77(0.69,4.55) | 0.238 |
TC/CC | 76/61 | 1.45(0.92,2.26) | 0.107 | 134/132 | 1.09(0.80,1.50) | 0.581 | 159/146 | 1.20(0.89,1.62) | 0.230 | 51/47 | 1.12(0.67,1.87) | 0.668 | 111/95 | 1.13(0.79,1.62) | 0.496 | 99/98 | 1.27(0.88,1.84) | 0.208 |
Additive model | 1.46(1.00,2.12) | 0.048 | 1.13(0.87,1.48) | 0.355 | 1.21(0.94,1.56) | 0.142 | 1.23(0.82,1.85) | 0.308 | 1.21(0.90,1.62) | 0.201 | 1.26(0.92,1.73) | 0.153 | ||||||
rs461404 | ||||||||||||||||||
AA | 91/106 | Reference | 179/192 | Reference | 195/214 | Reference | 75/84 | Reference | 151/146 | Reference | 119/152 | Reference | ||||||
GA | 64/56 | 1.34(0.84,2.13) | 0.218 | 115/119 | 1.05(0.75,1.45) | 0.792 | 139/133 | 1.16(0.85,1.58) | 0.347 | 40/42 | 1.00(0.58,1.72) | 0.991 | 91/86 | 1.03(0.71,1.49) | 0.891 | 88/89 | 1.25(0.85,1.83) | 0.255 |
GG | 13/5 | 3.12(1.05,9.27) | 0.040 | 19/12 | 1.64(0.76,3.53) | 0.207 | 20/12 | 1.84(0.87,3.87) | 0.109 | 12/5 | 2.46(0.82,7.36) | 0.108 | 20/9 | 2.16(0.95,4.91) | 0.068 | 12/8 | 1.96(0.77,4.97) | 0.156 |
GA/GG | 77/61 | 1.49(0.95,2.32) | 0.082 | 134/131 | 1.10(0.81,1.52) | 0.537 | 159/145 | 1.21(0.90,1.64) | 0.205 | 52/47 | 1.16(0.69,1.93) | 0.573 | 111/95 | 1.13(0.79,1.62) | 0.496 | 100/97 | 1.31(0.91,1.90) | 0.150 |
Additive model | 1.51(1.04,2.19) | 0.030 | 1.14(0.88,1.49) | 0.327 | 1.23(0.95,1.59) | 0.113 | 1.26(0.84,1.89) | 0.261 | 1.21(0.90,1.62) | 0.201 | 1.31(0.95,1.79) | 0.098 |