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Table 3 PRKAA1 Polymorphisms with Gastric Cancer Risk by Clinical Characteristics of Participants

From: Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer

Genotype Age Sex Helicobacter pylori infection.
≤60 >60 Male Female Positive Negative
Ca/Co OR (95% CI) P Ca/Co OR (95% CI)a P Ca/Co OR (95% CI)a P Ca/Co OR (95% CI)a P Ca/Co OR (95% CI)a P Ca/Co OR (95% CI)a P
rs10074991
 AA 33/45 Reference   71/83 Reference   69/62 Reference   35/36 Reference   52/57 Reference   52/71 Reference  
 AG 90/90 1.31(0.76,2.25) 0.331 165/171 1.10(0.75,1.62) 0.630 197/193 1.35(0.93,1.95) 0.117 58/68 0.77(0.42,1.41) 0.399 142/139 1.12(0.72,1.75) 0.613 113/122 1.26(0.81,1.96) 0.302
 GG 45/32 1.93(1.00,3.73) 0.050 77/69 1.20(0.76,1.91) 0.436 88/74 1.51(0.97,2.37) 0.070 34/27 1.27(0.63,2.58) 0.503 68/45 1.68(0.98,2.88) 0.060 54/56 1.31(0.77,2.22) 0.318
 AG/GG 135/122 1.46(0.87,2.45) 0.154 242/240 1.15(0.80,1.66) 0.461 285/267 1.40(0.98,1.99) 0.067 92/95 0.91(0.52,1.59) 0.734 210/184 1.26(0.82,1.93) 0.292 167/178 1.27(0.84,1.94) 0.255
 Additive model   1.40(1.01,1.93) 0.043   1.12(0.89,1.41) 0.332   1.25(1.01,1.56) 0.046   1.10(0.77,1.55) 0.611   1.30(0.99,1.69) 0.057   1.14(0.88,1.48) 0.313
rs13361707
 TT 33/46 Reference   70/83 Reference   68/93 Reference   36/35 Reference   51/58 Reference   52/71 Reference  
 TC 90/89 1.35(0.79,2.33) 0.273 166/171 1.12(0.76,1.65) 0.563 198/192 1.40(0.96,2.03) 0.080 58/68 0.77(0.42,1.41) 0.399 143/138 1.18(0.76,1.84) 0.465 113/122 1.26(0.81,1.96) 0.302
 CC 45/32 2.00(1.04,3.84) 0.039 77/69 1.22(0.77,1.94) 0.402 88/74 1.56(1.00,2.44) 0.052 34/27 1.27(0.63,2.58) 0.503 68/45 1.75(1.02,3.00) 0.042 54/56 1.31(0.77,2.22) 0.318
 TC/CC 135/121 1.51(0.90,2.53) 0.119 242/240 1.17(0.81,1.69) 0.408 286/266 1.44(1.01,2.06) 0.044 92/95 0.91(0.52,1.59) 0.734 211/183 1.32(0.86,2.03) 0.200 167/178 1.27(0.84,1.94) 0.255
 Additive model   1.41(1.02,1.95)   0.036 1.13(0.90,1.42) 0.305   1.27(1.02,1.58) 0.034   1.10(0.77,1.55) 0.611   1.32(1.01,1.73) 0.041   1.14(0.88,1.48) 0.313
rs154268
 TT 92/106 Reference   179/191 Reference   195/213 Reference   76/84 Reference   151/146 Reference   120/151 Reference  
 TC 64/56 1.32(0.83,2.10) 0.241 115/120 1.03(0.74,1.44) 0.844 140/134 0.81(0.60,1.10) 0.357 39/42 0.95(0.55,1.65) 0.866 91/86 1.03(0.71,1.49) 0.891 88/90 1.21(0.83,1.78) 0.315
 CC 12/5 2.77(0.92,8.33) 0.069 19/12 1.63(0.76,3.51) 0.210 19/12 1,73(0.81,3.67) 0.153 12/5 2.44(0.82,7.29) 0.111 20/9 2.16(0.95,4.91) 0.068 11/8 1.77(0.69,4.55) 0.238
 TC/CC 76/61 1.45(0.92,2.26) 0.107 134/132 1.09(0.80,1.50) 0.581 159/146 1.20(0.89,1.62) 0.230 51/47 1.12(0.67,1.87) 0.668 111/95 1.13(0.79,1.62) 0.496 99/98 1.27(0.88,1.84) 0.208
Additive model   1.46(1.00,2.12) 0.048   1.13(0.87,1.48) 0.355   1.21(0.94,1.56) 0.142   1.23(0.82,1.85) 0.308   1.21(0.90,1.62) 0.201   1.26(0.92,1.73) 0.153
rs461404
 AA 91/106 Reference   179/192 Reference   195/214 Reference   75/84 Reference   151/146 Reference   119/152 Reference  
 GA 64/56 1.34(0.84,2.13) 0.218 115/119 1.05(0.75,1.45) 0.792 139/133 1.16(0.85,1.58) 0.347 40/42 1.00(0.58,1.72) 0.991 91/86 1.03(0.71,1.49) 0.891 88/89 1.25(0.85,1.83) 0.255
 GG 13/5 3.12(1.05,9.27) 0.040 19/12 1.64(0.76,3.53) 0.207 20/12 1.84(0.87,3.87) 0.109 12/5 2.46(0.82,7.36) 0.108 20/9 2.16(0.95,4.91) 0.068 12/8 1.96(0.77,4.97) 0.156
 GA/GG 77/61 1.49(0.95,2.32) 0.082 134/131 1.10(0.81,1.52) 0.537 159/145 1.21(0.90,1.64) 0.205 52/47 1.16(0.69,1.93) 0.573 111/95 1.13(0.79,1.62) 0.496 100/97 1.31(0.91,1.90) 0.150
 Additive model   1.51(1.04,2.19) 0.030   1.14(0.88,1.49) 0.327   1.23(0.95,1.59) 0.113   1.26(0.84,1.89) 0.261   1.21(0.90,1.62) 0.201   1.31(0.95,1.79) 0.098
  1. aAdjusted for age, gender, smoking, drinking, and Helicobacter pylori infection; Ca, case; Co, control