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Table 3 PRKAA1 Polymorphisms with Gastric Cancer Risk by Clinical Characteristics of Participants

From: Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer

Genotype

Age

Sex

Helicobacter pylori infection.

≤60

>60

Male

Female

Positive

Negative

Ca/Co

OR (95% CI)

P

Ca/Co

OR (95% CI)a

P

Ca/Co

OR (95% CI)a

P

Ca/Co

OR (95% CI)a

P

Ca/Co

OR (95% CI)a

P

Ca/Co

OR (95% CI)a

P

rs10074991

 AA

33/45

Reference

 

71/83

Reference

 

69/62

Reference

 

35/36

Reference

 

52/57

Reference

 

52/71

Reference

 

 AG

90/90

1.31(0.76,2.25)

0.331

165/171

1.10(0.75,1.62)

0.630

197/193

1.35(0.93,1.95)

0.117

58/68

0.77(0.42,1.41)

0.399

142/139

1.12(0.72,1.75)

0.613

113/122

1.26(0.81,1.96)

0.302

 GG

45/32

1.93(1.00,3.73)

0.050

77/69

1.20(0.76,1.91)

0.436

88/74

1.51(0.97,2.37)

0.070

34/27

1.27(0.63,2.58)

0.503

68/45

1.68(0.98,2.88)

0.060

54/56

1.31(0.77,2.22)

0.318

 AG/GG

135/122

1.46(0.87,2.45)

0.154

242/240

1.15(0.80,1.66)

0.461

285/267

1.40(0.98,1.99)

0.067

92/95

0.91(0.52,1.59)

0.734

210/184

1.26(0.82,1.93)

0.292

167/178

1.27(0.84,1.94)

0.255

 Additive model

 

1.40(1.01,1.93)

0.043

 

1.12(0.89,1.41)

0.332

 

1.25(1.01,1.56)

0.046

 

1.10(0.77,1.55)

0.611

 

1.30(0.99,1.69)

0.057

 

1.14(0.88,1.48)

0.313

rs13361707

 TT

33/46

Reference

 

70/83

Reference

 

68/93

Reference

 

36/35

Reference

 

51/58

Reference

 

52/71

Reference

 

 TC

90/89

1.35(0.79,2.33)

0.273

166/171

1.12(0.76,1.65)

0.563

198/192

1.40(0.96,2.03)

0.080

58/68

0.77(0.42,1.41)

0.399

143/138

1.18(0.76,1.84)

0.465

113/122

1.26(0.81,1.96)

0.302

 CC

45/32

2.00(1.04,3.84)

0.039

77/69

1.22(0.77,1.94)

0.402

88/74

1.56(1.00,2.44)

0.052

34/27

1.27(0.63,2.58)

0.503

68/45

1.75(1.02,3.00)

0.042

54/56

1.31(0.77,2.22)

0.318

 TC/CC

135/121

1.51(0.90,2.53)

0.119

242/240

1.17(0.81,1.69)

0.408

286/266

1.44(1.01,2.06)

0.044

92/95

0.91(0.52,1.59)

0.734

211/183

1.32(0.86,2.03)

0.200

167/178

1.27(0.84,1.94)

0.255

 Additive model

 

1.41(1.02,1.95)

 

0.036

1.13(0.90,1.42)

0.305

 

1.27(1.02,1.58)

0.034

 

1.10(0.77,1.55)

0.611

 

1.32(1.01,1.73)

0.041

 

1.14(0.88,1.48)

0.313

rs154268

 TT

92/106

Reference

 

179/191

Reference

 

195/213

Reference

 

76/84

Reference

 

151/146

Reference

 

120/151

Reference

 

 TC

64/56

1.32(0.83,2.10)

0.241

115/120

1.03(0.74,1.44)

0.844

140/134

0.81(0.60,1.10)

0.357

39/42

0.95(0.55,1.65)

0.866

91/86

1.03(0.71,1.49)

0.891

88/90

1.21(0.83,1.78)

0.315

 CC

12/5

2.77(0.92,8.33)

0.069

19/12

1.63(0.76,3.51)

0.210

19/12

1,73(0.81,3.67)

0.153

12/5

2.44(0.82,7.29)

0.111

20/9

2.16(0.95,4.91)

0.068

11/8

1.77(0.69,4.55)

0.238

 TC/CC

76/61

1.45(0.92,2.26)

0.107

134/132

1.09(0.80,1.50)

0.581

159/146

1.20(0.89,1.62)

0.230

51/47

1.12(0.67,1.87)

0.668

111/95

1.13(0.79,1.62)

0.496

99/98

1.27(0.88,1.84)

0.208

Additive model

 

1.46(1.00,2.12)

0.048

 

1.13(0.87,1.48)

0.355

 

1.21(0.94,1.56)

0.142

 

1.23(0.82,1.85)

0.308

 

1.21(0.90,1.62)

0.201

 

1.26(0.92,1.73)

0.153

rs461404

 AA

91/106

Reference

 

179/192

Reference

 

195/214

Reference

 

75/84

Reference

 

151/146

Reference

 

119/152

Reference

 

 GA

64/56

1.34(0.84,2.13)

0.218

115/119

1.05(0.75,1.45)

0.792

139/133

1.16(0.85,1.58)

0.347

40/42

1.00(0.58,1.72)

0.991

91/86

1.03(0.71,1.49)

0.891

88/89

1.25(0.85,1.83)

0.255

 GG

13/5

3.12(1.05,9.27)

0.040

19/12

1.64(0.76,3.53)

0.207

20/12

1.84(0.87,3.87)

0.109

12/5

2.46(0.82,7.36)

0.108

20/9

2.16(0.95,4.91)

0.068

12/8

1.96(0.77,4.97)

0.156

 GA/GG

77/61

1.49(0.95,2.32)

0.082

134/131

1.10(0.81,1.52)

0.537

159/145

1.21(0.90,1.64)

0.205

52/47

1.16(0.69,1.93)

0.573

111/95

1.13(0.79,1.62)

0.496

100/97

1.31(0.91,1.90)

0.150

 Additive model

 

1.51(1.04,2.19)

0.030

 

1.14(0.88,1.49)

0.327

 

1.23(0.95,1.59)

0.113

 

1.26(0.84,1.89)

0.261

 

1.21(0.90,1.62)

0.201

 

1.31(0.95,1.79)

0.098

  1. aAdjusted for age, gender, smoking, drinking, and Helicobacter pylori infection; Ca, case; Co, control