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Fig. 3 | BMC Cancer

Fig. 3

From: Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma

Fig. 3

Intratumor heterogeneity. In the context of the stresses from the external environment and the need for nutritional sources, onco-evolution takes place in the solid tumor and various subclones form. Subclone B, for example, is a group of hypoxia-resistant tumor cells and subclone C is another group of invasive tumor cells known as ITF. These subclones undoubtedly possess their own molecular characteristics which poses a formidable hurdle in the process from biomarkers discovery to application

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