Fig. 1

Levels of MiR-126 in tissues and serum of studied populations and its biomarker performance. Box-plots showing MiR-126 levels in biopsies of normal mucosa (M), Intestinal-type adenocarcinomas (ITACs), sinonasal inverted papillomas (SIPs) and nasal inflammatory polyps (NIPs) shown as relative expression (2^-∆Ct) (a) or fold-change (b). c Relative expression of MiR-126 in serum of patients with ITACs and in healthy controls. d Receiver-operating curve (ROC) of serum MiR-126 to differentiate between ITAC patients and control subjects. MiR-126 yielded an AUC of 0.813 ± 0.064 with 80% sensitivity and 70% specificity in discriminating patients with SNC from healthy subjects, p < 0.0005. *Mucosa versus ITAC, SIP, and NIP groups, p < 0.05