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Table 4 Combined effects of H19 SNPs and cooking oil fume exposure on lung adenocarcinoma risk

From: Polymorphisms in the H19 gene and the risk of lung Cancer among female never smokers in Shenyang, China

SNP

 

Oil

Controls (%)

Cases (%)

OR (95%CI)*

P value

rs217727

CC

Non-exposure

86(32.3)

49(24.9)

1(ref)

 

CT + TT

Non-exposure

114(42.9)

77 (39.1)

1.180(0.748–1.859)

0.477

CC

Exposure

27(10.2)

23(11.7)

1.480(0.766–2.859)

0.243

CT + TT

Exposure

39(14.6)

48(24.4)

2.147(1.239–3.721)

0.006

rs2107425

CC

Non-exposure

70(26.3)

36(18.3)

1(ref)

 

CT + TT

Non-exposure

130(48.9)

90(45.7)

1.342(0.827–2.177)

0.233

CC

Exposure

25(9.4)

21(10.7)

1.614(0.796–3.273)

0.184

CT + TT

Exposure

41(15.4)

50(25.4)

2.362(1.327–4.204)

0.003

rs2735469

CT + TT

Non-exposure

18(6.8)

7(3.6)

1(ref)

 

CC

Non-exposure

182(68.4)

119(60.4)

1.679(0.680–4.145)

0.261

CT + TT

Exposure

9(3.4)

6(3.0)

1.697(0.438–6.570)

0.444

CC

Exposure

57(21.4)

65(33.0)

2.917(1.136–7.492)

0.026

rs17658052

GG

Non-exposure

188(70.7)

114(57.9)

1(ref)

 

GA + GG

Non-exposure

12(4.5)

12 (6.1)

1.647(0.716–3.791)

0.241

GG

Exposure

62(23.3)

68(34.5)

1.798(1.186–2.725)

0.006

GA + AA

Exposure

4(1.5)

3(1.5)

1.268(0.278–5.781)

0.759

  1. *: adjusted by age