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Table 2 Comparison of malignant transformation of total P16 methylation-positive and –negative oral epithelial dysplasia in patients with various baseline clinicopathological characteristics

From: A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study

Item   All cases Total-P16M -negative (P16U) Total-P16M -positive Odd ratio (95% CI) in univariate analysis
  n Total-P16M-positive rate (%) Cancer rate (%) n Cancer cases (%) n Cancer cases %)
Sex
 Male 112 25.0 8.9 84 5 (6.0) 28 5 (17.9)  
 Female 135 33.3 16.3 90 10 (11.1) 45 12 (26.7) 2.91 (1.15–7.39)
Age (yrs)
  < 60 153 26.8 11.8 112 9 (8.0) 41 9 (22.0) 3.22 (1.18–8.80)
 ≥ 60 94 34.0 14.9 62 6 (9.7) 32 8 (25.0)  
Cigarette smoking
 Yes 71 18.3 8.5 58 4 (6.9) 13 2 (15.4)  
 No 176 34.1 14.8 116 11 (9.5) 60 15 (25.0) 3.18 (1.36–7.47)
Alcohol drinking
 Yes 56 25.0 8.9 42 2 (4.8) 14 3 (21.4)  
 No 191 30.9 14.1 132 13 (9.8) 59 14(23.7) 2.85 (1.24–6.53)
Lesion grade
 Mild 164 26.2 11.6 121 10 (8.3) 43 9 (20.9) 2.94 (1.10–7.82)
 Mod. 83 36.1 15.7 53 5 (9.4) 30 8 (26.7) 3.49 (1.02–11.90)
Lesion site
 Tongue 109 37.6 22.0 a,c 68 9 (13.2) 41 15 (36.6) 3.78 (1.47–9.75)
 Others 138 23.2 5.8 106 6 (5.7) 32 2 (6.3)  
Center
 A 112 33.0 11.6 75 6 (8.0) 37 7 (18.9)  
 B 135 26.7 14.1 99 9 (9.1) 36 10 (27.8) 3.85 (1.41–10.46)
Sample storage
 Frozen 87 32.2 12.6 59 5 (8.5) 28 6 (21.4)  
 Paraffin 160 28.1 13.1 115 10 (8.7) 45 11 (24.4) 3.40 (1.33–8.69)
Total 247 29.6 13.0 174 15 (8.6) 73 17 (23.3) 3.22 (1.51–6.87) b,d
  1. a Tongue vs Other, P < 0.001; b Total-P16M-negative vs Total-P16M-positive, P = 0.002; c/d Adjusted-odds ratio: 0.22 (0.09–0.55)/2.67 (1.19–5.99) , respectively, after sex, age, smoking, alcohol use, lesion site, and lesion grade were adjusted in multivariate analysis. The values are presented in the bold letters when difference between two subgroups is statistically significant.