Table 2 Comparison of malignant transformation of total P16 methylation-positive and –negative oral epithelial dysplasia in patients with various baseline clinicopathological characteristics
Item | Â | All cases | Total-P16M -negative (P16U) | Total-P16M -positive | Odd ratio (95% CI) in univariate analysis | ||||
|---|---|---|---|---|---|---|---|---|---|
| Â | n | Total-P16M-positive rate (%) | Cancer rate (%) | n | Cancer cases (%) | n | Cancer cases %) | ||
Sex | |||||||||
 Male | 112 | 25.0 | 8.9 | 84 | 5 (6.0) | 28 | 5 (17.9) |  | |
 Female | 135 | 33.3 | 16.3 | 90 | 10 (11.1) | 45 | 12 (26.7) | 2.91 (1.15–7.39) | |
Age (yrs) | |||||||||
  < 60 | 153 | 26.8 | 11.8 | 112 | 9 (8.0) | 41 | 9 (22.0) | 3.22 (1.18–8.80) | |
 ≥ 60 | 94 | 34.0 | 14.9 | 62 | 6 (9.7) | 32 | 8 (25.0) |  | |
Cigarette smoking | |||||||||
 Yes | 71 | 18.3 | 8.5 | 58 | 4 (6.9) | 13 | 2 (15.4) |  | |
 No | 176 | 34.1 | 14.8 | 116 | 11 (9.5) | 60 | 15 (25.0) | 3.18 (1.36–7.47) | |
Alcohol drinking | |||||||||
 Yes | 56 | 25.0 | 8.9 | 42 | 2 (4.8) | 14 | 3 (21.4) |  | |
 No | 191 | 30.9 | 14.1 | 132 | 13 (9.8) | 59 | 14(23.7) | 2.85 (1.24–6.53) | |
Lesion grade | |||||||||
 Mild | 164 | 26.2 | 11.6 | 121 | 10 (8.3) | 43 | 9 (20.9) | 2.94 (1.10–7.82) | |
 Mod. | 83 | 36.1 | 15.7 | 53 | 5 (9.4) | 30 | 8 (26.7) | 3.49 (1.02–11.90) | |
Lesion site | |||||||||
 Tongue | 109 | 37.6 | 22.0 a,c | 68 | 9 (13.2) | 41 | 15 (36.6) | 3.78 (1.47–9.75) | |
 Others | 138 | 23.2 | 5.8 | 106 | 6 (5.7) | 32 | 2 (6.3) |  | |
Center | |||||||||
 A | 112 | 33.0 | 11.6 | 75 | 6 (8.0) | 37 | 7 (18.9) |  | |
 B | 135 | 26.7 | 14.1 | 99 | 9 (9.1) | 36 | 10 (27.8) | 3.85 (1.41–10.46) | |
Sample storage | |||||||||
 Frozen | 87 | 32.2 | 12.6 | 59 | 5 (8.5) | 28 | 6 (21.4) |  | |
 Paraffin | 160 | 28.1 | 13.1 | 115 | 10 (8.7) | 45 | 11 (24.4) | 3.40 (1.33–8.69) | |
Total | 247 | 29.6 | 13.0 | 174 | 15 (8.6) | 73 | 17 (23.3) | 3.22 (1.51–6.87) b,d | |