Table 1 Clinical characteristics of patients with oral epithelial dysplasia enrolled into the final follow-up analysis
Status of P16 methylation and hydroxymethylation | Total-P16M- negative | Total-P16M-positive | Total | ||
|---|---|---|---|---|---|
Subgroup | (P16U) | (All) | True-P16M | P16H | |
Case number | 174 | 73 | 50 | 23 | 247 |
Age (yrs, mean±SD) | 55.9±10.3 | 58.1±9.7 | 59.3±9.4 | 55.4±10.1 | 56.6±10.2 |
Sex ratio (male, %) | 48.3 | 38.4 | 36.0 | 43.5 | 45.3 |
Cigarette smoking (yes, %) | 33.3 | 17.8 a | 22.0 | 8.7 | 28.7 |
Alcohol drinking (yes, %) | 24.1 | 19.2 | 18.0 | 21.7 | 22.7 |
Baseline grade (mild, %) | 69.5 | 58.9 | 58.0 | 60.9 | 59.9 |
Lesion site (tongue, %) | 39.1 | 56.2 b | 54.0 | 60.9 | 44.1 |
Oral Leukoplakia (%) | 69.1 | 30.9 | 21.7 | 9.2 | (n = 217) |
Oral Lichen Planus (%) | 79.3 | 20.7 | 10.3 | 10.3 | (n = 29) |
Discoid lupus erythematous | 1 | 0 | 0 | 0 | (n = 1) |