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Table 1 Clinical characteristics of patients with oral epithelial dysplasia enrolled into the final follow-up analysis

From: A similar effect of P16 hydroxymethylation and true-methylation on the prediction of malignant transformation of oral epithelial dysplasia: observation from a prospective study

Status of P16 methylation and hydroxymethylation Total-P16M- negative Total-P16M-positive Total
Subgroup (P16U) (All) True-P16M P16H
Case number 174 73 50 23 247
Age (yrs, mean±SD) 55.9±10.3 58.1±9.7 59.3±9.4 55.4±10.1 56.6±10.2
Sex ratio (male, %) 48.3 38.4 36.0 43.5 45.3
Cigarette smoking (yes, %) 33.3 17.8 a 22.0 8.7 28.7
Alcohol drinking (yes, %) 24.1 19.2 18.0 21.7 22.7
Baseline grade (mild, %) 69.5 58.9 58.0 60.9 59.9
Lesion site (tongue, %) 39.1 56.2 b 54.0 60.9 44.1
Oral Leukoplakia (%) 69.1 30.9 21.7 9.2 (n = 217)
Oral Lichen Planus (%) 79.3 20.7 10.3 10.3 (n = 29)
Discoid lupus erythematous 1 0 0 0 (n = 1)
  1. a/b Fish exact-test, P16U vs total-P16M-positive (All): P = 0.014/0.017