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Table 4 Stepwise Cox regression analysis of key characteristics at baseline including CCI items with univariate p < 0.1 (all items of CCI are shown in Table 3)

From: Local ablation or radioembolization of colorectal cancer metastases: comorbidities or older age do not affect overall survival

Variable

Univariate p

HR (95% CI)

Multivariate p*

HR (95% CI)

CCI items p < 0.1

 Chronic pulmonary disease

0.046*

0.61 (0.38–0.99)

0.30

0.76 (0.45–1.28)

 Peptic ulcer disease

0.006*

7.40 (1.80–30.50)

0.17

2.75 (0.65–11.69)

 Moderate/severe renal disease

0.005*

2.3 (1.29–4.13)

0.005

2.46 (1.32–4.57)

Comorbidities not included in CCI

 Hypertension

0.54

0.93 (0.72–1.20)

  

 Obesity

0.32

0.77 (0.47–1.28)

  

 Hyperlipidemia

0.48

0.84 (0.51–1.37)

  

Patient and treatment characteristics

 Age > 70 years

0.19

0.84 (0.64–1.10)

  

 CCI ≥ 3

0.41

1.15 (0.82–1.62)

  

 Positive N stage of primary

0.004*

1.27 (1.08–1.50)

0.25

1.11 (0.93–1.33)

 Synchronous metastases

0.036*

1.36 (1.02–1.81)

0.90

0.98 (0.71–1.35)

 Metachronous lymph node metastases

0.032*

1.44 (1.03–2.00)

0.17

1.31 (0.89–1.91)

 Metachronous pulmonary metastases

0.55

1.09 (0.83–1.43)

  

 1st/2nd Line vs. 3rd Line treatment

0.001*

0.83 (0.77–0.90)

0.30

0.89 (0.72–1.1)

 Salvage treatment in Y90-RE

0.001*

2.17 (1.37–3.45)

< 0.001

4.35 (3.06–6.17)

  1. *multivariate Cox regression analysis including all variables p < 0.1 in univariate analysis