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Table 4 Stepwise Cox regression analysis of key characteristics at baseline including CCI items with univariate p < 0.1 (all items of CCI are shown in Table 3)

From: Local ablation or radioembolization of colorectal cancer metastases: comorbidities or older age do not affect overall survival

Variable Univariate p HR (95% CI) Multivariate p* HR (95% CI)
CCI items p < 0.1
 Chronic pulmonary disease 0.046* 0.61 (0.38–0.99) 0.30 0.76 (0.45–1.28)
 Peptic ulcer disease 0.006* 7.40 (1.80–30.50) 0.17 2.75 (0.65–11.69)
 Moderate/severe renal disease 0.005* 2.3 (1.29–4.13) 0.005 2.46 (1.32–4.57)
Comorbidities not included in CCI
 Hypertension 0.54 0.93 (0.72–1.20)   
 Obesity 0.32 0.77 (0.47–1.28)   
 Hyperlipidemia 0.48 0.84 (0.51–1.37)   
Patient and treatment characteristics
 Age > 70 years 0.19 0.84 (0.64–1.10)   
 CCI ≥ 3 0.41 1.15 (0.82–1.62)   
 Positive N stage of primary 0.004* 1.27 (1.08–1.50) 0.25 1.11 (0.93–1.33)
 Synchronous metastases 0.036* 1.36 (1.02–1.81) 0.90 0.98 (0.71–1.35)
 Metachronous lymph node metastases 0.032* 1.44 (1.03–2.00) 0.17 1.31 (0.89–1.91)
 Metachronous pulmonary metastases 0.55 1.09 (0.83–1.43)   
 1st/2nd Line vs. 3rd Line treatment 0.001* 0.83 (0.77–0.90) 0.30 0.89 (0.72–1.1)
 Salvage treatment in Y90-RE 0.001* 2.17 (1.37–3.45) < 0.001 4.35 (3.06–6.17)
  1. *multivariate Cox regression analysis including all variables p < 0.1 in univariate analysis