Decreased methylation in the SNAI2 and ADAM23 genes associated with de-differentiation and haematogenous dissemination in breast cancers

Table 4 The risk estimation of analysed variables and clinical status for histological grade 3 in breast cancer patients (logistic regression adjusted for age)

	Variables	P value	OR	95% CI
Grade 3	↑ Methylation of SNAI2 in PT	0.038	0.61	0.39–0.97
	Ki-67 proliferation index > 20%	0.002	17.34	2.89–103.88

−2 Log likelihood = 31.62; R²(Cox and Snell) = 0.43; R²(Nagelkerke) = 0.60
Abbreviations: PT primary tumour, OR odds ratio, CI confidence interval, ↑ continuous variable. Age and DNA methylation of EMT related genes, hormone receptor and HER2 status, histological type and Ki-67 proliferative index were analysed as independent variables, significant results are shown in the table

ISSN: 1471-2407