Table 3 Adverse Events in the Patients with Adult NKTCL (n = 33)
Common adverse event | I | II | III | IV | n (%) |
|---|---|---|---|---|---|
Systemic reactions | |||||
 Allergic reaction | 0 | 0 | 0 | 0 | 0 (0.0) |
 Drug fever | 0 | 0 | 0 | 0 | 0 (0.0) |
 Infection | 2 | 1 | 1 | 0 | 4 (12.1) |
Hyperglycemia | 3 | 0 | 0 | 0 | 3 (9.1) |
Coagulation function | |||||
 Decreased fibrinogen | 14 | 1 | 0 | 0 | 15 (45.5) |
 Prolonged APTT |  |  |  |  | a19(57.6) |
 Prolonged PT |  |  |  |  | a9 (27.3) |
 Thrombosis | 0 | 1 | 0 | 0 | 1 (3.0) |
 Hemorrhage | 0 | 0 | 0 | 0 | 0 (0.0) |
Blood system | |||||
 Neutropenia | 2 | 2 | 7 | 14 | 25 (75.8) |
 Anemia | 8 | 3 | 1 | 0 | 12 (36.4) |
 Thrombocytopenia | 5 | 2 | 1 | 0 | 8 (24.2) |
Gastrointestinal tract | |||||
 Increase in ALT/AST | 17 | 2 | 3 | 0 | 22 (66.7) |
 Increase in bilirubin | 11 | 0 | 0 | 0 | 11 (33.3) |
 Pancreatitis | 0 | 0 | 0 | 0 | 0 (0.0) |
 Vomiting | 4 | 4 | 0 | 0 | 8 (24.2) |
 Diarrhea | 0 | 0 | 1 | 0 | 1 (3.0) |
Respiratory system | |||||
 Cough | 0 | 0 | 0 | 0 | 0 (0.0) |
 Chest tightness | 0 | 0 | 0 | 0 | 0 (0.0) |
 Bronchial spasm | 0 | 0 | 0 | 0 | 0 (0.0) |
Cardiovascular system | |||||
 Arrhythmia | 0 | 0 | 0 | 0 | 0 (0.0) |
 Hypotension | 0 | 0 | 0 | 0 | 0 (0.0) |
 Cardiac insufficiency | 0 | 0 | 0 | 0 | 0 (0.0) |
Nervous system | |||||
 Headache | 0 | 0 | 0 | 0 | 0 (0.0) |
 Insomnia | 0 | 0 | 0 | 0 | 0 (0.0) |
 Mental change | 0 | 0 | 0 | 0 | 0 (0.0) |
Urinary system | |||||
 Renal damage | 0 | 0 | 0 | 0 | 0 (0.0) |
 Urine color change | 0 | 0 | 0 | 0 | 0 (0.0) |
Other events | 1 | 1 | 0 | 0 | 2 (6.0) |