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Table 1 Participant eligibility criteria

From: Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

Inclusion criteria Exclusion criteria
 • ≥ 18 years of age
 • Female
 • Able to read and communicate in English
 • Diagnosis of stage IA-IIIC breast cancer
 • Scheduled to receive anthracycline-containing chemotherapy
 • Willing and able to adhere to either intervention
 • Contraindications to research MRI (e.g. pacemaker, magnetic implant)
 • Contraindications to maximal exercise testing
 • Pregnancy
 • Limitations to sustained exercise on all potential modes (i.e., treadmill, elliptical, bike)
 • Body mass index <19 kg/m2 or history of eating disorder
 • Diabetes
 • Severe food allergies or diet restrictions