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Table 1 Participant eligibility criteria

From: Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

Inclusion criteria

Exclusion criteria

 • ≥ 18 years of age

 • Female

 • Able to read and communicate in English

 • Diagnosis of stage IA-IIIC breast cancer

 • Scheduled to receive anthracycline-containing chemotherapy

 • Willing and able to adhere to either intervention

 • Contraindications to research MRI (e.g. pacemaker, magnetic implant)

 • Contraindications to maximal exercise testing

 • Pregnancy

 • Limitations to sustained exercise on all potential modes (i.e., treadmill, elliptical, bike)

 • Body mass index <19 kg/m2 or history of eating disorder

 • Diabetes

 • Severe food allergies or diet restrictions