Fig. 1From: Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancerStudy design. Note: Most patients at the Cross Cancer Institute will receive three anthracycline cycles total, followed by additional chemotherapy treatments (typically taxanes). In the case where patients receive more than three anthracycline treatments, the intervention will be applied to all cycles receivedBack to article page