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Table 3 Results of pathological fractures of both groups

From: Local response and pathologic fractures following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for spinal metastases - a randomized controlled trial

 

SBRT group

3DCRT group

p-value

N

n/n (new)

%

95% CI

N

n/n (new)

%

95% CI

 

Pathological fracture

All metastases

  Baseline (T0)

27

11

40.7

0.224–0.621

28

5

17.9

0.061–0.369

0.062

  3 months (T2)

23

11/(2)

47.8

0.268–0.694

23

5/(1)

21.7

0.075–0.437

0.063

  6 months (T3)

18

11/(5)

61.1

0.358–0.827

20

6/(1)

30.0

0.119–0.543

0.054

Subgroup analysis

Osteolytic metastases

  Baseline (T0)

8

2

25.0

0.032–0.651

4

0

0

0

0.273

  3 months (T2)

6

3/(2)

50.0

0.118–0.882

4

1/(1)

25.0

0.006–0.806

0.429

  6 months (T3)

6

3

50.0

0.118–0.882

3

1

33.3

0.008–0.906

0.635

Osteoblastic metastases

  Baseline (T0)

2

0

0

 

5

0

0

  

  3 months (T2)

2

0

0

 

4

0

0

  

  6 months (T3)

1

0

0

 

4

0

0

  

Mixed metastases

  Baseline (T0)

17

9

52.9

0.278–0.770

18

4

22.2

0.064–0.476

0.060

  3 months (T2)

15

8

53.33

0.266–0.787

14

3

21.4

0.047–0.508

0.077

  6 months (T3)

11

8/(5)

72.7

0.390–0.940

12

4/(1)

33.3

0.099–0.651

0.059

  1. Abbreviations: N alive patients in group, n (new) number of new pathological fractures in the total number of pathological fractures, CI confidence interval