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Table 2 Bone density in metastatic bone before RT, as well as 3 and 6 months after RT

From: Local response and pathologic fractures following stereotactic body radiotherapy versus three-dimensional conformal radiotherapy for spinal metastases - a randomized controlled trial

 

SBRT group

  

Within group

3DCRT group

  

Within group

Differences between groups

 

n

Median

IQR

p-value

n

Median

IQR

 

HL

95% CI

p-value

All metastases

 HU Baseline

27

219.0

141.0–364.0

 

28

248.0

155.0–307.0

 

−11

−66.0-55.0

0.762

 HU T2

23

231.0

196.0–420.0

 

23

310.0

234.0–428.0

 

−29

−100.0-63.0

0.455

 HU T3

18

336.5

215.0–481

 

20

363.5

218.5–463.5

 

−2.5

− 117.0-105.0

0.942

3 months

 HU T0-T2

23

65.0

22.0–107.0

< 0.01

23

64.0

16.0–108.0

< 0.01

5.0

−40.0-52.0

0.860

 HU T0-T2 (%)

23

33.8

12.0–69.6

< 0.01

23

32.9

5.3–48.1

< 0.01

5.4

−17.6-30.0

0.629

6 months

 HU T0-T3

18

95.0

50.0–208.0

< 0.01

20

97.5

59.5–158.0

< 0.01

19.5

−50.0-106.0

0.714

 HU T0-T3 (%)

18

72.1

15.2–95.7

< 0.01

20

41.2

18.9–55.0

< 0.01

29.2

−21.4-58.4

0.327

Subgroup analysis

 Osteolyltic metastases

  HU Baseline

8

164.0

116.0–240.0

 

4

149.0

127.0–248.0

 

−0.5

− 147.0-197.0

1.000

  HU T2

6

234.0

156.0–480

 

4

219.0

181.0–503.0

 

23.5

−334.0-616.0

0.749

  HU T3

6

312.5

200.0–481.0

 

3

222.0

204.0–794

 

14.5

− 351.0-614.0

0.699

3 months

 HU T0-T2

6

69.5

64.0–133.0

0.031

4

70.0

54.0–255.0

0.125

1.0

−213.0-370.0

1.000

 HU T0-T2 (%)

6

53.9

33.8–86.7

0.031

4

46.9

42.2–88.3

0.125

8.6

−60.4-94.6

0.594

6 months

 HU T0-T3

6

165.5

88.0–208.0

0.031

3

64.0

64.0–456.0

0.250

−24.0

− 156.0-396.0

0.899

 HU T0-T3 (%)

6

85.8

59.9–95.7

0.031

3

45.7

40.5–134.9

0.250

−29.0

− 146.2-92.1

0.519

  1. This results demonstrated the bone density (HU = Hounsfield units) in metastatic bone before RT (baseline), 3 and 6 months after RT. The results were presented by absolute and relative values (%) of HU within and between group as median (Hodges–Lehmann estimate) and IQR
  2. Abbreviations: HU Hounsfield units, IQR interquartile range, T0 baseline, T2 3 months, T3 6 months, T0–T2 difference baseline minus 3 months, T0-T3 difference baseline minus 6 months, HL Hodges-Lehmann estimator, 95% CI 95% Confidence Interval