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Table 4 Cox regression analyses of combined MRN expression with disease-free survival

From: Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

  n (%) Univariate Multivariate
HR 95% CI P Value HR 95% P Value
MRN TCa
 High 81.9 2.069 1.102–3.882 0.024* 2.114 1.096–4.078 0.026*
 Low 18.1       
Sex
 Male 66.4 1.041 0.633–1.711 0.876    
 Female 33.6       
Age
 ≤70 46.0 1.294 0.789–2.125 0.307    
 > 70 54.0       
Tumor stage
 T1–2 33.6 1.501 0.897–2.512 0.122    
 T3–4 66.4       
Node stage
 Negative 54.3 1.44 0.976–2.126 0.066    
 Positive 45.7       
Grade
 1–2 92.5 1.537 0.823–2.872 0.178    
 3 7.5       
Vascular invasion
 Absent 76.3 1.167 0.638–2.134 0.617    
 Present 23.7       
Perineural invasion
 Absent 84.0 2.334 1.310–4.157 0.004* 2.16 1.209–3.859 0.009*
 Present 16.0       
Adjuvant therapy
 No 69.5 0.602 0.341–1.063 0.08    
 Yes 30.5       
Neoadjuvant therapy
 No 78.0 0.855 0.529–1.381 0.521    
 Yes 22.0       
MRN TC by LNb
 LN-negative 54.1     1.339 0.589–3.042 0.486
 LN-positive 45.9     3.472 1.051–11.454 0.047*
  1. HR hazard ratio, CI confidence interval, TC tumor center, LN lymph node
  2. aThree marker combined expression in the tumor center; b denotes interaction
  3. *p < 0.05 was considered significant