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Table 3 Associations between combined MRN expression in the tumor center or periphery and clinicohistopathological data

From: Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

  Tumor Center Tumor Periphery
Low (%) High (%) P value Low (%) High (%) P value
Sex
 Male 62.5 66.8 0.567 80.0 64.6 0.121
 Female 37.5 33.2   20.0 35.4  
Age
 ≤70 43.8 46.5 0.751 36.0 47.1 0.290
 > 70 56.2 53.5   64.0 52.9  
Tumor stage
 T1–2 50.0 30.0 0.009* 44.0 32.5 0.246
 T3–4 50.0 70.0   56.0 67.5  
Node stage
 Negative 60.0 53.1 0.395 52.0 54.5 0.811
 Positive 40.0 46.9   48.0 45.5  
Metastasis stage
 M0 97.8 91.7 0.147 100 92.1 0.153
 M1 2.2 8.3   0 7.9  
Grade
 1–2 93.8 92.2 0.707 88.0 92.9 0.376
 3 6.2 7.8   12.0 7.1  
Vascular invasion
 Absent 82.6 75 0.27 84 75.5 0.343
 Present 17.4 25   16 24.5  
Perineural invasion
 Absent 84.8 83.8 0.869 92 83.1 0.250
 Present 15.2 16.2   8 16.9  
Adjuvant therapy
 No 70.0 69.4 0.945 52.4 71.4 0.072
 Yes 30.0 30.6   47.6 28.6  
Neoadjuvant therapy
 No 65.2 80.9 0.021* 68 78 0.205
 Yes 34.8 19.1   32 22  
MSH6
 Negative 0 100 0.518 0 100 0.663
 Positive 17.3 82.7   8.7 91.3  
PMS2
 Negative 11.1 88.9 0.669 0 100 0.345
 Positive 16.5 84.5   9.1 90.9  
  1. *p < 0.05 was considered significant