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Table 3 Summary and subgroup analysis for the eligible studies

From: Tumor necrosis as a prognostic variable for the clinical outcome in patients with renal cell carcinoma: a systematic review and meta-analysis

Analysis specification No. of studies Study heterogeneity Effects model Pooled HR(95% CI) p-Value
I2 (%) Pheterogeneity
CSS
 Overall 22 76.5 < 0.001 Random 1.37(1.23,1.53) < 0.001
 Geographical region
  Asian 7 51.7 0.053 Random 1.34(1.12,1.59) 0.001
  Other regions 15 80.8 < 0.001 Random 1.40(1.22,1.60) < 0.001
 Pathological types
  ccRCC 6 0 0.775 Fixed 1.34(1.15,1.55) < 0.001
  Other types 16 81.7 < 0.001 Random 1.38(1.22,1.58) < 0.001
 Staging system
  2010 AJCC 8 0 0.981 Fixed 1.30(1.17,1.44) < 0.001
  Other system 14 82.3 < 0.001 Random 1.42(1.23,1.64) < 0.001
 No. of patients
   ≥ 300 13 82 < 0.001 Random 1.39(1.21,1.61) < 0.001
   < 300 9 15,4 0.301 Fixed 1.33(1.16,1.51) < 0.001
 Median follow-up
   ≥ 40 months 12 83.3 < 0.001 Random 1.36(1.16,1.60) < 0.001
   < 40 months 9 30.2 0.177 Fixed 1.33(1.16,1.51) < 0.001
OS
 Overall 17 57.6 0.002 Random 1.29(1.20,1.40) < 0.001
 Geographical region
  Asian 9 30.2 0.177 Fixed 1.38(1.25,1.51) < 0.001
  Other regions 8 58.6 0.017 Random 1.20(1.09,1.34) < 0.001
 Pathological types
  ccRCC 8 48.8 0.057 Random 1.33(1.19,1.49) < 0.001
  Other types 9 62.7 0.006 Random 1.26(1.13,1.41) < 0.001
 Staging system
  2010 AJCC 10 63.6 0.003 Random 1.30(1.17,1.44) < 0.001
  Other system 7 53.1 0.046 Random 1.30(1.14,1.47) < 0.001
 No. of patients
   ≥ 300 8 67.5 0.003 Random 1.25(1.12,1.39) < 0.001
   < 300 9 29.2 0.185 Fixed 1.35(1.22,1.49) < 0.001
 Median follow-up
   ≥ 40 months 13 62.6 0.001 Random 1.27(1.16,1.39) < 0.001
   < 40 months 4 0 0.412 Fixed 1.37(1.20,1.56) < 0.001
RFS
 Overall 9 35.6 0.133 Fixed 1.55(1.39,1.72) < 0.001
 Geographical region
  Asian 6 42.7 0.12 Fixed 1.48(1.31,1.66) < 0.001
  Other regions 3 0 0.684 Fixed 1.87(1.41,2.37) < 0.001
 Pathological types
  ccRCC 4 0 0.541 Fixed 1.61(1.40,1.86) < 0.001
  Other types 5 57.5 0.051 Random 1.46(1.25,1.71) < 0.001
 Staging system
  2010 AJCC 5 54 0.069 Random 1.48(1.31,1.69) < 0.001
  Other system 4 0 0.483 Fixed 1.69(1.40,2.04) < 0.001
 No. of patients
   ≥ 300 4 0 0.702 Fixed 1.57(1.35,1.83) < 0.001
   < 300 5 63.4 0.027 Random 1.52(1.32,1.76) < 0.001
 Median follow-up
   ≥ 40 months 6 0 0.758 Fixed 1.62(1.43,1.84) < 0.001
   < 40 months 3 75.3 0.018 Random 1.39(1.16,1.68) 0.001
PFS
 Overall 5 32.9 0.202 Fixed 1.31(1.17,1.46) < 0.001
 Pathological types
  ccRCC 2 67.8 0.078 Random 1.44(1.20,1.71) < 0.001
  Other types 3 0 0.6 Fixed 1.23(1.07,1.41) 0.004
 Staging system
  2010 AJCC 2 76.3 0.04 Random 1.35(1.18,1.54) < 0.001
  Other system 3 0 0.582 Fixed 1.22(1.01,1.48) 0.036