Fig. 5
From: Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas
Lumbar puncture-administered resveratrol inhibits proliferation and induces apoptosis in glioblastoma cells. a H&E demonstration of extensive cell death caused by postoperative lumbar punctured (LP) resveratrol. The dashed line defines the tumour margin and the arrow indicates the tumour tissue with apoptosis. b TUNEL labelling performed on the operated tumours without (control) and with lumbar punctured resveratrol (LP). Right side, the incidences of TUNEL-positive cells in the two experimental groups. c Ki67 immunohistochemical staining performed on the tumours without (control) and with postoperative lumbar punctured resveratrol (LP). Right side, the incidences of Ki67-positive cells in the two experimental groups. d Transmission electron microscopic image of the operated tumor tissue without (Upper) and with LP resveratrol treatment (Below)