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Table 1 % case survival from cancer of the vulva by period post-diagnosis; South Australian major public hospitals, 1984–2016 diagnosesa

From: Using hospital registries in Australia to extend data availability on vulval cancer treatment and survival

Number of cases

Surv 1 yr

Surv 2 yr

Surv 5 yr

Surv 10 yr

Surv 20 yr

p value**

Hazard ratiob (95% CLs) -adjusted

All (n = 383)

84.1

75.7

70.0

61.5

55.3

  

Age at diagnosis (yrs.):

 < 50 (n = 56)

96.4

91.1

91.1

82.8

75.6

p < 0.001

1.00

 50–69 (n = 100)

86.6

83.5

77.4

65.6

57.6

2.10 (1.06, 4.17)

 70–79 (n = 113)

82.0

66.6

59.1

51.9

45.0

3.14 (1.65, 6.00)

 80+ (n = 114)

77.8

70.5

63.6

56.1

52.6

2.25 (1.16, 4.40)

FIGO stage:

 I (n = 167)

94.5

92.0

85.8

77.7

70.1

p < 0.001

1.00

 II (n = 103)

92.2

81.5

71.6

61.4

55.5

1.62 (1.04, 2.53)

 III (n = 68)

68.3

43.5

41.8

34.1

28.9

3.89 (2.47, 6.13)

 IV (n = 29)

27.6

27.6

27.6

27.6

7.29 (3.94, 13.49)

 (Unknown (n = 16))

(93.8)

(93.8)

(93.8)

(76.7)

(68.2)

(1.06 (0.37, 3.09))

Differentiation:

 Well (n = 102)

93.1

86.1

79.9

69.9

60.3

p < 0.001

1.00

 Moderate (n = 136)

84.1

74.8

70.1

62.5

56.2

0.80 (0.51, 1.25)

 Poorly/undifferentiated (n = 75)

69.1

54.0

46.9

41.9

40.1

1.71 (1.06, 2.76)

 (Unknown (n = 70)

(86.8)

(85.3)

(79.8)

(66.8)

(63.6)

(0.94 (0.51, 1.71))

Histology:

 Squamous cell carcinoma (n = 341)

85.1

76.0

69.8

61.1

55.1

p = 0.955

1.00

 Other (n = 42)

75.9

73.4

70.9

64.1

57.4

0.69 (0.40, 1.21)

Socioeconomic (SEIFA):

 Low (n = 138)

84.5

76.8

74.3

66.7

59.2

p = 0.684

1.00

 Low/med (n = 75)

87.7

80.8

73.7

55.5

55.5

1.25 (0.78, 2.02)

 Med/high (n = 77)

88.1

77.4

68.7

58.7

53.2

1.19 (0.76, 1.88)

 High (n = 93)

77.4

68.7

61.8

61.8

52.0

1.14 (0.73, 1.76)

Geographic remoteness:

 Low (n = 314)

83.5

75.0

69.1

60.8

55.0

p = 0.534

1.00

 Moderate (n = 45)

86.0

76.5

76.5

70.4

62.8

1.00 (0.56, 1.79)

 High (n = 24)

87.5

83.3

70.1

56.1

48.1

1.40 (0.76, 2.59)

Diagnostic period (calendar years.):

 1984–99 (n = 199)

83.9

76.4

71.9

63.3

56.7

p = 0.498

1.00

 2000–16 (n = 184)

84.6

74.9

67.6

59.3

0.88 (0.61, 1.27)

  1. **Derived from unadjusted Cox proportional hazards regression
  2. aKaplan-Meier product-limit disease-specific estimates; date of censoring of live cases - Dec 31, 2016
  3. bDerived from Cox proportional hazards regression, adjusting for other variables in the Table