Fig. 4

Drug sensitivity and resistance testing of tamoxifen resistant cells. DSS scores [42] of (a) CTG-measurement and (b) cell count are displayed as heatmap with dark orange showing the most effective drugs. c Quantification of LipidToxGreen staining in cells grown +/− 1 μM 4-OH-tamoxifen reveals an increase in the mean intensities of the staining in tamoxifen resistant cell lines. Only significant differences (p-value < 0.05) between the same clone as well as of the comparison between resistant and tamoxifen-resistant cells in the same treatment conditions are indicated all other comparisons can be found in Additional file 3. d TO901317 (concentration in nM) increases the LipidToxGreen staining mainly in the parental cell lines