Skip to main content
Fig. 1 | BMC Cancer

Fig. 1

From: Association of tamoxifen resistance and lipid reprogramming in breast cancer

Fig. 1

Tamoxifen-resistant cell lines display distinct expression changes and share similarities with patient cases. a Hierarchical clustering and heat map visualization of each parental/resistant cell line pair. Orange (negative log2-ratio) represents increase and blue (positive log2-ratio) decrease in expression in the resistant cell lines. Only protein coding genes with log2 ratioā€‰>ā€‰|1| and the difference of gene expression > |10| CPM in at least one of the comparisons are displayed. Log2 ratios of >ā€‰=ā€‰|2| are displayed in the same color. Tamoxifen-resistant clones (b) and patient samples (c) differ in their expression changes. Parental is compared with resistant cell line and primary tumor with metastatic tumor from the same patient, respectively. Venn diagrams show overlap in numbers and percentage of genes that are differentially expressed. d PCA plot indicates that patients share expression patterns with the luminal A cells

Back to article page