Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysis

Li, Qiuping; Ma, Chao; Zhang, Zhihui; Chen, Suhua; Zhi, Weiguo; Zhang, Lei; Zhang, Guoyao; Shi, Lei; Cao, Fei; Ma, Tianjiang

doi:10.1186/s12885-018-4753-3

Table 1 Characteristics of studies included in the meta-analysis

From: Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysis

First author	Year	Ethnicity	Country	Control source	Cancer type	Genotype method	cases			controls			HWE	MAF
First author	Year	Ethnicity	Country	Control source	Cancer type	Genotype method	TT	TC	CC	TT	TC	CC	HWE	MAF
Cox, D.G.	2004	Caucasian	Spain	HB	colorectal	Invader	140	121	29	126	120	25	0.639	0.314
Campa, D.	2004	Caucasian	France	PB	lung	TaqMan	31	107	112	65	99	50	0.304	0.465
Hu, Z.	2005	Asian	China	HB	lung	PCR-PIRA	234	83	5	209	107	7	0.113	0.187
Sorensen, M.	2005	Caucasian	Denmark	PB	lung	TaqMan	127	111	18	115	126	27	0.377	0.336
Campa, D.	2005	Caucasian	France	PB	lung	TaqMan	855	886	224	805	904	228	0.285	0.351
Sakoda, L.C.	2006	Asian	China	PB	AV	TaqMan	30	11	4	541	216	21	0.920	0.166
Gallicchio, L.	2006	Mixed	USA	PB	breast	TaqMan	9	5	0	158	164	34	0.360	0.326
Gallicchio, L.	2006	Mixed	USA	PB	breast	TaqMan	29	26	11	396	416	95	0.353	0.334
Siezen, C.L.	2006	Caucasian	Netherlands	PB	colorectal	Pyrosequencing	97	83	20	190	163	35	0.996	0.300
Siezen, C.L.	2006	Caucasian	Netherlands	PB	colorectal	Pyrosequencing	216	171	55	339	281	73	0.198	0.308
Sakoda, L.C.	2006	Asian	China	PB	EHBD	TaqMan	70	51	5	541	216	21	0.920	0.166
Sakoda, L.C.	2006	Asian	China	PB	gallbladder	TaqMan	165	61	10	541	216	21	0.920	0.166
Park, J.M.	2006	Asian	Korea	HB	lung	PCR-PIRA	352	205	25	330	220	32	0.552	0.244
Shahedi, K.	2006	Caucasian	Sweden	PB	prostate	MassARRAY	571	618	158	306	363	88	0.208	0.356
Cox, D.G.	2007	Mixed	USA	PB	breast	TaqMan	541	567	141	699	808	213	0.383	0.359
Cox, D.G.	2007	Mixed	USA	PB	breast	TaqMan	140	131	30	270	259	81	0.134	0.345
Cox, D.G.	2007	Mixed	USA	PB	breast	TaqMan	281	296	67	278	294	79	0.925	0.347
Gao, J.	2007	Asian	China	HB	breast	PCR-RFLP	404	179	18	429	194	20	0.733	0.182
Vogel, U.	2007	Caucasian	Denmark	PB	breast	PCR-RFLP	167	150	44	155	165	41	0.770	0.342
Lee, T.S.	2007	Asian	Korea	HB	cervical	SNP-IT	115	52	8	101	50	2	0.124	0.176
Campa, D.	2007	Caucasian	France	PB	esophageal	TaqMan	64	84	11	389	377	87	0.756	0.323
Jiang, G.J.	2007	Asian	China	HB	gastric	PCR-PIRA	159	86	9	199	96	9	0.525	0.188
Hou, L.F.	2007	Caucasian	Poland	PB	gastric	TaqMan	137	132	35	165	202	49	0.279	0.361
Campa, D.	2007	Caucasian	France	PB	laryngeal	TaqMan	139	120	22	313	321	77	0.694	0.334
Campa, D.	2007	Caucasian	France	PB	nasopharyngeal	TaqMan	41	47	11	313	321	77	0.694	0.334
Campa, D.	2007	Caucasian	France	PB	oral	TaqMan	72	70	11	313	321	77	0.694	0.334
Cheng, I.	2007	African	USA	HB	prostate	TaqMan	12	39	38	11	49	29	0.162	0.601
Cheng, I.	2007	Caucasian	USA	HB	prostate	TaqMan	183	199	34	196	177	44	0.668	0.318
Lira, M.G.	2007	Caucasian	Italy	HB	skin	PCR-RFLP	44	47	12	64	51	15	0.330	0.312
Vogel, U.	2007	Caucasian	Denmark	PB	skin	TaqMan	123	140	41	145	148	22	0.054	0.305
Yang, H	2008	Mixed	USA	HB	bladder	SNPlex	279	268	76	236	312	85	0.255	0.381
Song, D.K.	2008	Asian	China	HB	bladder	PCR-PIRA	132	39	4	113	61	5	0.337	0.198
Ferguson, H.R.	2008	Caucasian	UK	HB	esophageal	TaqMan	73	106	30	111	113	24	0.537	0.325
Vogel, U.	2008	Caucasian	Denmark	PB	lung	PCR-RFLP	182	183	38	310	341	93	0.959	0.354
Danforth, K.N.	2008	Caucasian	USA	PB	prostate	TaqMan	488	515	143	641	605	137	0.741	0.318
Danforth, K.N.	2008	Caucasian	USA	PB	prostate	TaqMan	517	507	113	501	517	117	0.332	0.331
Abraham, J.E.	2009	Caucasian	UK	PB	breast	TaqMan	927	985	260	996	1010	259	0.903	0.337
Andersen, V	2009	Caucasian	Denmark	PB	colorectal	TaqMan	147	178	34	315	355	95	0.745	0.356
Gong, Z.H	2009	Mixed	USA	PB	colorectal	PCR-RFLP	64	70	28	69	109	33	0.351	0.415
Thompson, C.L.	2009	Caucasian	USA	PB	colorectal	TaqMan	176	189	56	216	199	65	0.081	0.343
Upadhyay, R.	2009	Asian	India	HB	esophageal	PCR-RFLP	63	89	22	81	102	33	0.924	0.389
Srivastava, K.	2009	Asian	India	HB	gallbladder	PCR-RFLP	51	91	25	67	88	29	0.991	0.397
Piranda, D.N.	2010	Mixed	Brazil	PB	breast	TaqMan	125	149	20	120	99	25	0.496	0.305
Dossus, L.	2010	Mixed	Germany	PB	breast	IGG	2697	2664	772	3512	3501	933	0.180	0.338
Pandey, S.	2010	Asian	India	HB	cervical	PCR-RFLP	104	90	6	102	82	16	0.932	0.285
Pereira, C.	2010	Caucasian	Portugal	HB	colorectal	TaqMan	54	51	10	118	114	24	0.638	0.316
Lurie, G.	2010	Mixed	USA	PB	ovarian	TaqMan	169	120	13	338	207	47	0.058	0.254
Lurie, G.	2010	Caucasian	USA	PB	ovarian	TaqMan	333	304	86	490	469	136	0.151	0.338
Gangwar, R.	2011	Asian	India	PB	bladder	PCR-RFLP	82	106	24	97	119	34	0.794	0.374
Brasky, T.M.	2011	Caucasian	USA	PB	breast	TaqMan	432	447	108	732	782	226	0.450	0.355
Akkiz, H.	2011	Caucasian	Turkey	HB	HCC	PCR-RFLP	65	56	8	58	62	9	0.161	0.310
Lim, W.Y.	2011	Asian	Singapore	HB	lung	TaqMan	182	100	15	462	228	28	0.984	0.198
Ozhan, G.	2011	Caucasian	Turkey	HB	pancreatic	PCR-RFLP	74	60	19	71	59	20	0.176	0.330
Mandal, R.K.	2011	Asian	India	HB	prostate	PCR-RFLP	71	86	38	105	113	32	0.853	0.354
Gomez, L.M.	2011	Caucasian	Italy	PB	skin	PCR-RFLP	56	65	17	56	50	18	0.221	0.347
Li, H.Z.	2012	Asian	China	PB	gastric	TaqMan	1048	534	67	1276	568	56	0.450	0.179
Guo, S.J	2012	Asian	China	HB	lung	PCR-RFLP	486	185	15	389	181	32	0.075	0.203
Fawzy, M.S.	2013	Caucasian	Egypt	HB	breast	PCR-RFLP	53	71	36	69	67	14	0.694	0.317
Andersen, V	2013	Caucasian	Denmark	PB	colorectal	PCR-KASP	430	404	97	720	815	203	0.228	0.351
Makar, K.W.	2013	Mixed	USA	PB	colorectal	IGG	851	920	232	1067	1149	333	0.392	0.356
Makar, K.W.	2013	Mixed	USA	PB	colorectal	IGG	552	582	157	887	940	258	0.713	0.349
Ruan, Y.F.	2013	Asian	China	HB	colorectal	PCR-PIRA	98	27	5	80	37	3	0.597	0.179
Song, H.L.	2013	Asian	China	HB	endometrial	PCR-RFLP	68	27	5	69	26	5	0.233	0.180
Lu, Y.J.	2013	Asian	China	HB	esophageal	PCR-RFLP	76	36	7	179	54	5	0.698	0.134
Chang, J.S.	2013	Asian	China	HB	HN	TaqMan	209	89	15	199	86	10	0.850	0.180
Qian, Q.	2014	Asian	China	HB	bladder	TaqMan	4	26	24	1	32	64	0.164	0.825
Gao, J.	2014	Asian	China	HB	breast	TaqMan	299	132	34	515	244	40	0.117	0.203
Vogel, L.K.	2014	Caucasian	Denmark	PB	colorectal	TaqMan	69	87	33	169	191	39	0.156	0.337
Shao, S.S.	2014	Asian	China	HB	HCC	PCR-RFLP	160	92	18	357	164	19	0.975	0.187
Niu, Y.	2014	Asian	China	PB	laryngeal	TaqMan	59	27	4	691	316	25	0.112	0.177
Bhat, I.A.	2014	Asian	India	HB	lung	PCR-RFLP	133	53	4	128	66	6	0.470	0.195
Lan, X.H.	2014	Asian	China	HB	oral	PCR-RFLP	35	14	2	65	32	10	0.053	0.243
Niu, Y.	2014	Asian	China	PB	oral	TaqMan	118	45	5	691	316	25	0.112	0.177
Gao, F.	2015	Asian	China	HB	gastric	TaqMan	171	100	13	193	77	4	0.232	0.155
Lin, R.P.	2015	Asian	China	HB	glioma	TaqMan	129	66	5	109	77	14	0.936	0.263
Cao, Q.	2015	Asian	China	HB	lung	PCR-RFLP	16	19	7	22	25	3	0.233	0.310
Mamoghli, T.	2015	Caucasian	Tunisia	HB	nasopharyngeal	PCR-RFLP	100	80	9	110	99	28	0.433	0.327
Wang, J.L.	2015	Asian	China	HB	nasopharyngeal	PCR-RFLP	139	129	28	110	149	41	0.398	0.385
Moraes, J.L.	2017	Mixed	Brazil	HB	lung	TaqMan	44	43	17	69	106	25	0.107	0.390

Abbreviations: HWE Hardy-Weinberg equilibrium, MAF minor allele frequecy, HB hospital based, PB population based, AV ampulla of vater, EHBD extrahepatic bile duct, HCC hepatocellular carcinoma, HN head and neck, PCR-RFLP polymorphism chain reaction restriction fragment length polymorphism, PCR-PIRA polymorphism chain reaction based primer-introduced restriction analysis, PCR-KASP polymorphism chain reaction based kompetitive allele specific, IGG Illumina GoldenGate

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ISSN: 1471-2407

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