Table 2 Univariate Cox proportional hazards regression analysis for overall survival and relapse-free survival in gastric carcinoma patients
Characteristics | No. | OS | P | RFS | P |
|---|---|---|---|---|---|
HR (95% CI) | HR (95% CI) | ||||
Age, y, ≥ 60 (vs < 60) | 117/169 | 1.254 (0.802–1.963) | 0.321 | 1.280 (0.819–2.001) | 0.278 |
Sex, male (vs female) | 128/169 | 0.956 (0.597–1.529) | 0.851 | 0.978 (0.612–1.563) | 0.926 |
CEA, elevated (vs normal) | 31/141 | 1.802 (1.100–2.952) | 0.019 | 1.783 (1.090–2.918) | 0.021 |
CA19–9, elevated (vs normal) | 16/140 | 2.055 (1.109–3.809) | 0.022 | 1.946 (1.051–3.604) | 0.034 |
TNM stage | |||||
I | 34/169 | 1 | < 0.001 | 1 | < 0.001 |
II | 44/169 | 2.154 (0.932–4.976) | 0.073 | 2.146 (0.929–4.958) | 0.074 |
III | 64/169 | 5.773 (2.694–12.370) | < 0.001 | 6.070 (2.834–13.001) | < 0.001 |
IV | 27/169 | 8.753 (3.840–19.953) | < 0.001 | 8.846 (3.884–20.147) | < 0.001 |
Venous invasion, presence (vs absence) | 30/169 | 3.360 (2.108–5.357) | < 0.001 | 3.336 (2.094–5.314) | < 0.001 |
Tumor invasion, AGC (vs EGC) | 133/169 | 3.510 (1.811–6.803) | < 0.001 | 3.592 (1.853–6.960) | < 0.001 |
Histologic grade | |||||
WD | 10/117 | 1 | 0.104 | 1 | 0.118 |
MD | 64/117 | 2.456 (0.756–7.978) | 0.135 | 2.444 (0.752–7.941) | 0.137 |
PD | 43/117 | 3.325 (1.011–10.936) | 0.048 | 3.248 (0.987–10.683) | 0.053 |
Ox-PTP nucleus, positive (vs negative) | 115/169 | 5.799 (3.084–10.905) | < 0.001 | 5.954 (3.167–11.192) | < 0.001 |
Ox-PTP cytoplasm, positive (vs negative) | 82/169 | 1.863 (1.238–2.803) | 0.003 | 1.982 (1.319–2.978) | < 0.001 |
ɣH2AX, positive (vs negative) | 97/169 | 2.774 (1.768–4.352) | < 0.001 | 2.607 (1.671–4.066) | < 0.001 |