Table 1 Clinicopathologic variables and the expression of nuclear and cytoplasmic expression of expression of Ox-PTP and γH2AX in gastric carcinoma patients
Characteristics | No. | Ox-PTP, nucleus | Ox-PTP, cytoplasm | ɣH2AX | ||||
|---|---|---|---|---|---|---|---|---|
Positive | P | Positive | P | Positive | P | |||
Age (years) | < 60 y | 52 | 34 (65%) | 0.621 | 27 (52%) | 0.555 | 18 (35%) | < 0.001 |
≥ 60 y | 117 | 81 (69%) | 55 (47%) | 79 (68%) | ||||
Sex | Female | 41 | 28 (68%) | 0.969 | 16 (39%) | 0.162 | 23 (56%) | 0.847 |
Male | 128 | 87 (68%) | 66 (52%) | 74 (58%) | ||||
CEAa | Normal | 110 | 74 (67%) | 0.463 | 50 (45%) | 0.215 | 60 (55%) | 0.022 |
Elevated | 31 | 23 (74%) | 18 (58%) | 24 (77%) | ||||
CA19–9a | Normal | 124 | 85 (69%) | 0.599 | 62 (50%) | 0.346 | 72 (58%) | 0.193 |
Elevated | 16 | 12 (75%) | 6 (38%) | 12 (75%) | ||||
T category | 1 | 36 | 17 (47%) | 0.012 | 16 (44%) | 0.555 | 17 (47%) | 0.550 |
2 | 17 | 10 (59%) | 7 (41%) | 10 (59%) | ||||
3 | 20 | 15 (75%) | 13 (65%) | 11 (55%) | ||||
4a | 73 | 53 (73%) | 34 (47%) | 43 (59%) | ||||
4b | 23 | 20 (87%) | 12 (52%) | 16 (70%) | ||||
N category | 0 | 60 | 29 (48%) | < 0.001 | 26 (43%) | 0.074 | 28 (47%) | 0.043 |
1 | 22 | 16 (73%) | 8 (36%) | 11 (50%) | ||||
2 | 33 | 21 (64%) | 14 (42%) | 19 (58%) | ||||
3 | 54 | 49 (61%) | 34 (63%) | 39 (72%) | ||||
M category | 0 | 165 | 112 (68%) | 0.763 | 80 (48%) | 0.952 | 94 (57%) | 0.471 |
1 | 4 | 3 (75%) | 2 (50%) | 3 (75%) | ||||
TNM stage | I | 34 | 15 (44%) | < 0.001 | 14 (41%) | 0.777 | 15 (44%) | 0.188 |
II | 44 | 25 (57%) | 21 (48%) | 24 (55%) | ||||
II | 64 | 52 (81%) | 33 (52%) | 39 (61%) | ||||
IV | 27 | 23 (85%) | 14 (52%) | 19 (70%) | ||||
Venous invasion | Absence | 139 | 92 (66%) | 0.264 | 66 (47%) | 0.561 | 76 (55%) | 0.124 |
Presence | 30 | 23 (77%) | 16 (53%) | 21 (70%) | ||||
WHO classification | Tubular | 115 | 86 (75%) | 0.091 | 66 (57%) | 0.030 | 72 (63%) | 0.055 |
SRC | 18 | 11 (61%) | 6 (33%) | 9 (50%) | ||||
Mucinous | 17 | 7 (41%) | 4 (24%) | 5 (29%) | ||||
Mixed | 15 | 9 (60%) | 4 (27%) | 7 (47%) | ||||
Papillary | 2 | 1 (50%) | 1 (50%) | 2 (100%) | ||||
Neuroendocrine | 2 | 1 (50%) | 1 (50%) | 2 (100%) | ||||
Histologic gradeb | WD | 10 | 4 (40%) | 0.002 | 7 (70%) | 0.182 | 7 (70%) | 0.248 |
MD | 64 | 55 (86%) | 40 (63%) | 44 (69%) | ||||
PD | 43 | 28 (65%) | 20 (47%) | 23 (53%) | ||||
Lauren classification | Intestinal | 71 | 54 (76%) | 0.079 | 47 (66%) | < 0.001 | 48 (68%) | 0.037 |
Diffuse | 73 | 43 (59%) | 25 (34%) | 34 (47%) | ||||
Mixed | 25 | 18 (72%) | 10 (40%) | 15 (60%) | ||||
ɣH2AX | Negative | 72 | 38 (53%) | < 0.001 | 28 (39%) | 0.031 | ||
Positive | 97 | 77 (79%) | 54 (56%) | |||||
Ox-PTP, cytoplasm | Negative | 87 | 38 (44%) | < 0.001 | ||||
Positive | 82 | 77 (94%) | ||||||