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Table 3 Interactions of O. viverrini infection intensity with IL-1β and TNF-α polymorphisms on the risk of intrahepatic cholangiocarcinoma in Thailand

From: Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study

Polymorphisms O. viverrini infection intensity Cases Controls ORa 95% CI P-value P-valueb
n n
IL-1B C-511 T IgG antibody       0.52
 CC OD ≤ 0.24 8 27 1.0    
 CT OD ≤ 0.24 17 56 0.9 0.4–2.5 0.90  
 TT OD ≤ 0.24 7 26 0.9 0.3–3.1 0.88  
 CC OD > 0.24 32 42 2.5 0.9–6.6 0.06  
 CT OD > 0.24 82 129 2.1 0.9–4.9 0.10  
 TT OD > 0.24 24 72 1.1 0.4–2.8 0.89  
TNF-A G-308A IgG antibody       0.64
 GG OD ≤ 0.24 18 73 1.0    
 GA OD ≤ 0.24 5 20 0.9 0.3–2.8 0.87  
 AA OD ≤ 0.24 8 14 2.2 0.8–6.0 0.14  
 GG OD > 0.24 87 169 2.1 1.2–3.7 0.01  
 GA OD > 0.24 24 38 2.4 1.1–4.9 0.02  
 AA OD > 0.24 27 37 2.8 1.4–5.8 0.01  
  1. aCrude odds ratios from matched case-control analysis
  2. bP -value for interaction