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Table 3 Interactions of O. viverrini infection intensity with IL-1β and TNF-α polymorphisms on the risk of intrahepatic cholangiocarcinoma in Thailand

From: Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study

Polymorphisms

O. viverrini infection intensity

Cases

Controls

ORa

95% CI

P-value

P-valueb

n

n

IL-1B C-511 T

IgG antibody

     

0.52

 CC

OD ≤ 0.24

8

27

1.0

   

 CT

OD ≤ 0.24

17

56

0.9

0.4–2.5

0.90

 

 TT

OD ≤ 0.24

7

26

0.9

0.3–3.1

0.88

 

 CC

OD > 0.24

32

42

2.5

0.9–6.6

0.06

 

 CT

OD > 0.24

82

129

2.1

0.9–4.9

0.10

 

 TT

OD > 0.24

24

72

1.1

0.4–2.8

0.89

 

TNF-A G-308A

IgG antibody

     

0.64

 GG

OD ≤ 0.24

18

73

1.0

   

 GA

OD ≤ 0.24

5

20

0.9

0.3–2.8

0.87

 

 AA

OD ≤ 0.24

8

14

2.2

0.8–6.0

0.14

 

 GG

OD > 0.24

87

169

2.1

1.2–3.7

0.01

 

 GA

OD > 0.24

24

38

2.4

1.1–4.9

0.02

 

 AA

OD > 0.24

27

37

2.8

1.4–5.8

0.01

 
  1. aCrude odds ratios from matched case-control analysis
  2. bP -value for interaction