Table 3 Interactions of O. viverrini infection intensity with IL-1β and TNF-α polymorphisms on the risk of intrahepatic cholangiocarcinoma in Thailand
Polymorphisms | O. viverrini infection intensity | Cases | Controls | ORa | 95% CI | P-value | P-valueb |
|---|---|---|---|---|---|---|---|
n | n | ||||||
IL-1B C-511 T | IgG antibody | 0.52 | |||||
CC | OD ≤ 0.24 | 8 | 27 | 1.0 | |||
CT | OD ≤ 0.24 | 17 | 56 | 0.9 | 0.4–2.5 | 0.90 | |
TT | OD ≤ 0.24 | 7 | 26 | 0.9 | 0.3–3.1 | 0.88 | |
CC | OD > 0.24 | 32 | 42 | 2.5 | 0.9–6.6 | 0.06 | |
CT | OD > 0.24 | 82 | 129 | 2.1 | 0.9–4.9 | 0.10 | |
TT | OD > 0.24 | 24 | 72 | 1.1 | 0.4–2.8 | 0.89 | |
TNF-A G-308A | IgG antibody | 0.64 | |||||
GG | OD ≤ 0.24 | 18 | 73 | 1.0 | |||
GA | OD ≤ 0.24 | 5 | 20 | 0.9 | 0.3–2.8 | 0.87 | |
AA | OD ≤ 0.24 | 8 | 14 | 2.2 | 0.8–6.0 | 0.14 | |
GG | OD > 0.24 | 87 | 169 | 2.1 | 1.2–3.7 | 0.01 | |
GA | OD > 0.24 | 24 | 38 | 2.4 | 1.1–4.9 | 0.02 | |
AA | OD > 0.24 | 27 | 37 | 2.8 | 1.4–5.8 | 0.01 |