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Table 2 Odds ratios for intrahepatic cholangiocarcinoma associated with O. viverrini infection intensity, and with IL-1β  and TNF-α polymorphisms

From: Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study

Variables

Cases

Controls

ORa

95% CI

P-value

ORb

95% CI

P-value

n

%

n

%

O. viverrini-IgG antibody

0.02

  

0.01

 OD ≤ 0.24

32

18.8

109

31.0

1.0

  

1.0

  

 OD > 0.24

138

81.2

243

69.0

2.0

1.3–3.1

 

2.1

1.2–3.9

 

IL-1B C-511 T polymorphisms

0.05

  

0.22

 CC

40

23.6

69

19.5

1.0

  

1.0

  

 CT

99

58.2

187

52.8

0.9

0.6–1.4

 

0.8

0.4–1.5

 

 TT

31

18.2

98

27.7

0.5

0.3–0.9

 

0.4

0.2–0.8

 

TNF-A G-308A polymorphisms

0.19

  

0.30

 GG

105

61.8

244

68.8

1.0

  

1.0

  

 GA

29

17.1

58

16.3

1.1

0.7–1.8

 

1.2

0.6–2.4

 

 AA

36

21.1

53

14.9

1.6

1.0–2.6

 

1.7

0.9–3.3

 
  1. aCrude odds ratios from matched case-control analysis
  2. bAdjusted for smoking (no/yes), alcohol drinking (< 14/≥14 units of alcohol per month), dietary consumption: dish of raw freshwater fish, processed beef, papaya salad (non-consumer, < 1/month & monthly, weekly, daily), total fruits (< 52/≥52 average times per month), and total vegetables (< 35/≥35 average times per month)