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Table 2 Odds ratios for intrahepatic cholangiocarcinoma associated with O. viverrini infection intensity, and with IL-1β  and TNF-α polymorphisms

From: Opisthorchiasis with proinflammatory cytokines (IL-1β and TNF-α) polymorphisms influence risk of intrahepatic cholangiocarcinoma in Thailand: a nested case-control study

Variables Cases Controls ORa 95% CI P-value ORb 95% CI P-value
n % n %
O. viverrini-IgG antibody 0.02    0.01
 OD ≤ 0.24 32 18.8 109 31.0 1.0    1.0   
 OD > 0.24 138 81.2 243 69.0 2.0 1.3–3.1   2.1 1.2–3.9  
IL-1B C-511 T polymorphisms 0.05    0.22
 CC 40 23.6 69 19.5 1.0    1.0   
 CT 99 58.2 187 52.8 0.9 0.6–1.4   0.8 0.4–1.5  
 TT 31 18.2 98 27.7 0.5 0.3–0.9   0.4 0.2–0.8  
TNF-A G-308A polymorphisms 0.19    0.30
 GG 105 61.8 244 68.8 1.0    1.0   
 GA 29 17.1 58 16.3 1.1 0.7–1.8   1.2 0.6–2.4  
 AA 36 21.1 53 14.9 1.6 1.0–2.6   1.7 0.9–3.3  
  1. aCrude odds ratios from matched case-control analysis
  2. bAdjusted for smoking (no/yes), alcohol drinking (< 14/≥14 units of alcohol per month), dietary consumption: dish of raw freshwater fish, processed beef, papaya salad (non-consumer, < 1/month & monthly, weekly, daily), total fruits (< 52/≥52 average times per month), and total vegetables (< 35/≥35 average times per month)