Table 3 Univariate and multivariate Cox proportional regression analysis of factors associating with DFS and OS
Variables | Disease-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Age, > 50 years vs. ≤ 50 years | 0.739(0.398–1.373) | 0.339 | 0.466 (0.207–1.054) | 0.067 | ||||
Sex, male vs. female | 0.505(0.156–1.637) | 0.255 | 0.574 (0.136–2.431) | 0.451 | ||||
HBsAg, positive vs. negative | 2.528(0.780–8.192) | 0.122 | 4.966 (0.673–36.617) | 0.116 | ||||
Liver cirrhosis, yes vs. no | 0.568(0.303–1.065) | 0.078 | 0.799 (0.362–1.765) | 0.580 | ||||
Child-Pugh score, B vs. A | 1.398(0.430–4.543) | 0.577 | 1.977 (0.590–6.624) | 0.269 | ||||
No. of tumors, multiple vs. single | 2.287(1.209–4.327) | 0.011 | 0.939(0.475–1.855) | 0.856 | 3.223(1.505–6.902) | 0.003 | 1.379 (0.618–3.078) | 0.432 |
Tumor size, ≤ 5 cm vs. > 5 cm | 10.403(3.710–29.173) | 0.000 | 4.840(1.518–15.428) | 0.008 | 27.058 (3.679–199.020) | 0.001 | 11.728 (1.448–94.962) | 0.021 |
Macroscopic tumor thrombus, yes vs. no | 6.836(3.567–13.100) | 0.000 | 2.588(1.174–5.706) | 0.018 | 8.194 (3.646–18.413) | 0.000 | 2.795 (1.084–7.206) | 0.033 |
Vascular invasion, yes vs. no | 6.145(3.124–12.085) | 0.000 | 1.816(0.766–4.307) | 0.176 | 5.933 (2.584–13.622) | 0.000 | 1.491 (0.510–4.357)) | 0.466 |
AFP, positive vs. negative | 2.349(1.043–5.288) | 0.039 | 1.172(0.474–2.899) | 0.731 | 2.781 (0.966–8.001) | 0.058 | 1.709 (0.548–5.332) | 0.356 |
BCLC stage, B + C vs. 0 + A | 8.695(3.103–24.370) | 0.000 | 11.212 (2.663–47.204) | 0.001 | ||||
Group | 0.529(0.414–0.676) | 0.000 | 0.620(0.479–0.803) | 0.000 | 0.484 (0.357–0.656) | 0.000 | 0.608 (0.443–0.834) | 0.002 |