Fig. 1
From: Tracing the path of cancer initiation: the AA protein-based model for cancer genesis
Simplified AA protein-based model for cancer genesis: In a normal cell AA protein forms one unit. In pre-malignant cells a pathological breakup of AA generates two entities A1 and A2, marking the switch from normalcy-to-malignancy. Both A1 & A2 acquire each a new activity not present in non-transformed cells. A2 infiltrates the stroma cells and also marks sites for metastases to form. C: cytoplasm; N: nucleus