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Table 4 Prognostic significance of PIK3CA alterations in esophageal cancer

From: PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue

Author Sample size (N) Histology Type of PIK3CA alterations Frequency (%) Prognostic effect HR (95% CI) Material Method
Maeng et al. (2012) [17] 80 ESCC Exon 9 and 20 mutations 11.5 N.S. NA Primary& Metastatic sites FFPE Mass-spectrometry based assay
Shigaki et al. (2013) [19] 219 ESCC Exon 9 and 20 mutations 21 Favorable OS 0.35 (0.10–0.90) Surgically resected FFPE Pyrosequencing
Hou et al. (2014) [16] 96 ESCC Exon 9 and 20 mutations 12.5 Trend towards favorable OS NA Surgically resected FFPE Mutant enriched PCR method
Wang et al. (2014) [21] 406 ESCC Exon 9 mutations 7.4 N.S. 1.256 (0.748–2.108) Surgically resected FFPE Direct sequencing
Kim et al. (2016) [23] 534 ESCC Amplification 10.5 Trend towards unfavorable OS 1.21 (0.83–1.77) Surgically resected FFPE Fluorescent in situ hybridization
388 Exon 9 and 20 mutations 1.5 N.S. NA Direct sequencing
Liu et al. (2017) [22] 210 ESCC Exon 9 mutations 22.9 Favorable OS NA Surgically resected FFPE Pyrosequencing
Current study 126 Mostly ESCC Exon 9 and 20 mutations 11.1 Favorable OS 0.34 (0.12–0.96) Surgically resected FFPE MPS with TSACP
Amplification 2.4 N.S. 2.66 (0.64–11.05)
  1. Abbreviations: OS overall survival, HR hazard ratio, CI confidence interval, NA not available, FFPE formalin-fixed paraffin-embedded, N.S. not significant, ESCC esophageal squamous cell carcinoma, MPS massively parallel sequencing, TSACP TruSeq® Amplicon Cancer Panel