Table 3 PIK3CA status and associated clinicopathological factors (n = 126)
Variable | PIK3CA mutant | PIK3CA wild type | Â | ||
|---|---|---|---|---|---|
N | % | N | % | p-value | |
Age | |||||
 < 65 | 7 | 50.0 | 63 | 56.3 | 0.7776 |
 ≥ 65 | 7 | 50.0 | 49 | 43.8 |  |
Gender | |||||
 Male | 13 | 92.9 | 99 | 88.4 | 1.0000 |
 Female | 1 | 7.1 | 13 | 11.6 |  |
Smoking status | |||||
 0 | 0 | 0.0 | 14 | 12.5 |  |
 1 | 6 | 42.9 | 16 | 14.3 | 0.06858 |
 2 | 2 | 14.3 | 28 | 25.0 |  |
 3 | 6 | 42.9 | 54 | 48.2 |  |
Location | |||||
 Ce | 0 | 0.0 | 2 | 1.8 | 0.9269 |
 Ut | 1 | 7.1 | 13 | 11.6 |  |
 Mt | 6 | 42.9 | 43 | 38.4 |  |
 Lt | 7 | 50.0 | 46 | 41.1 |  |
 Ae | 0 | 0.0 | 8 | 7.1 |  |
Histology | |||||
 SCC | 14 | 100.0 | 102 | 91.1 | 0.6007 |
 Others | 0 | 0.0 | 10 | 8.9 |  |
TNMÂ (UICC6th) | |||||
 T1 | 0 | 0.0 | 5 | 4.5 | 0.2775 |
 T2 | 1 | 7.1 | 5 | 4.5 |  |
 T3 | 12 | 85.7 | 101 | 90.2 |  |
 T4 | 1 | 7.1 | 1 | 0.9 |  |
 N0 | 4 | 28.6 | 26 | 23.2 | 0.7402 |
 N1 | 10 | 71.4 | 86 | 76.8 |  |
 M0 | 11 | 78.6 | 93 | 83.0 | 0.4465 |
 M1a | 2 | 14.3 | 7 | 6.3 |  |
 M1b | 1 | 7.1 | 12 | 10.7 |  |
Adjuvant | |||||
 NAC | 7 | 50.0 | 58 | 51.8 | 1.0000 |
 No NAC | 7 | 50.0 | 54 | 48.2 |  |
HER2 | |||||
 > median | 9 | 64.3 | 55 | 49.1 | 0.3969 |
 < median | 5 | 35.7 | 57 | 50.9 |  |
MET | |||||
 > median | 6 | 42.9 | 61 | 54.5 | 0.5715 |
 < median | 8 | 57.1 | 51 | 45.5 |  |
EGFR | |||||
 > median | 5 | 35.7 | 57 | 50.9 | 0.3969 |
 < median | 9 | 64.3 | 55 | 49.1 |  |
ALK | |||||
 > median | 7 | 50.0 | 55 | 49.1 | 1.0000 |
 < median | 7 | 50.0 | 57 | 50.9 |  |
HGF | |||||
 > median | 6 | 42.9 | 55 | 49.1 | 0.7796 |
 < median | 8 | 57.1 | 57 | 50.9 |  |
TP53 | |||||
 Wild type | 4 | 28.6 | 38 | 33.9 | 0.7728 |
 Mutation | 10 | 71.4 | 74 | 66.1 |  |
APC | |||||
 Wild type | 8 | 57.1 | 105 | 93.8 | 0.0007 |
 Mutation | 6 | 42.9 | 7 | 6.3 |  |
ERBB4 | |||||
 Wild type | 12 | 85.7 | 104 | 92.9 | 0.3070 |
 Mutation | 2 | 14.3 | 8 | 7.1 |  |
FBXW7 | |||||
 Wild type | 12 | 85.7 | 104 | 92.9 | 0.3070 |
 Mutation | 2 | 14.3 | 8 | 7.1 |  |
BRAF | |||||
 Wild type | 10 | 71.4 | 107 | 95.5 | 0.0090 |
 Mutation | 4 | 28.6 | 5 | 4.5 |  |
RB1 | |||||
 Wild type | 11 | 78.6 | 106 | 94.6 | 0.0618 |
 Mutation | 3 | 21.4 | 6 | 5.4 |  |