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Table 3 PIK3CA status and associated clinicopathological factors (n = 126)

From: PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue

Variable PIK3CA mutant PIK3CA wild type  
N % N % p-value
Age
 < 65 7 50.0 63 56.3 0.7776
 ≥ 65 7 50.0 49 43.8  
Gender
 Male 13 92.9 99 88.4 1.0000
 Female 1 7.1 13 11.6  
Smoking status
 0 0 0.0 14 12.5  
 1 6 42.9 16 14.3 0.06858
 2 2 14.3 28 25.0  
 3 6 42.9 54 48.2  
Location
 Ce 0 0.0 2 1.8 0.9269
 Ut 1 7.1 13 11.6  
 Mt 6 42.9 43 38.4  
 Lt 7 50.0 46 41.1  
 Ae 0 0.0 8 7.1  
Histology
 SCC 14 100.0 102 91.1 0.6007
 Others 0 0.0 10 8.9  
TNM (UICC6th)
 T1 0 0.0 5 4.5 0.2775
 T2 1 7.1 5 4.5  
 T3 12 85.7 101 90.2  
 T4 1 7.1 1 0.9  
 N0 4 28.6 26 23.2 0.7402
 N1 10 71.4 86 76.8  
 M0 11 78.6 93 83.0 0.4465
 M1a 2 14.3 7 6.3  
 M1b 1 7.1 12 10.7  
Adjuvant
 NAC 7 50.0 58 51.8 1.0000
 No NAC 7 50.0 54 48.2  
HER2
 > median 9 64.3 55 49.1 0.3969
 < median 5 35.7 57 50.9  
MET
 > median 6 42.9 61 54.5 0.5715
 < median 8 57.1 51 45.5  
EGFR
 > median 5 35.7 57 50.9 0.3969
 < median 9 64.3 55 49.1  
ALK
 > median 7 50.0 55 49.1 1.0000
 < median 7 50.0 57 50.9  
HGF
 > median 6 42.9 55 49.1 0.7796
 < median 8 57.1 57 50.9  
TP53
 Wild type 4 28.6 38 33.9 0.7728
 Mutation 10 71.4 74 66.1  
APC
 Wild type 8 57.1 105 93.8 0.0007
 Mutation 6 42.9 7 6.3  
ERBB4
 Wild type 12 85.7 104 92.9 0.3070
 Mutation 2 14.3 8 7.1  
FBXW7
 Wild type 12 85.7 104 92.9 0.3070
 Mutation 2 14.3 8 7.1  
BRAF
 Wild type 10 71.4 107 95.5 0.0090
 Mutation 4 28.6 5 4.5  
RB1
 Wild type 11 78.6 106 94.6 0.0618
 Mutation 3 21.4 6 5.4