Table 2 Factors associated with overall survival in univariate and multivariate analyses

Age

≥65 (vs. < 65)

1.11 (0.68–1.79)

0.68

1.25 (0.74–2.11)

0.40

Male

Male (vs. Female)

2.36 (0.86–6.49)

0.096

2.48 (0.86–7.20)

0.094

2.30 (0.83–6.36)

0.11

Smoking status

2–3 (vs 0–1)

1.22 (0.71–2.13)

0.47

0.74 (0.40–1.36)

0.33

cT

T3 (vs. T1, T2)

4.25 (1.04–17.41)

0.044

5.23 (1.19–23.00)

0.029

4.30 (1.04–17.70)

0.044

cN

N1 (vs. N0)

1.52 (0.84–2.75)

0.16

1.12 (0.57–2.19)

0.75

NAC

Without (vs. with)

1.01 (0.62–1.65)

0.97

0.88 (0.52–1.50)

0.65

HER2

>median (vs. <median)

0.93 (0.57–1.50)

0.76

0.92 (0.54–1.55)

0.75

MET

>median (vs. <median)

0.75 (0.46–1.21)

0.24

0.74 (0.44–1.27)

0.28

EGFR

>median (vs. <median)

0.99 (0.61–1.60)

0.97

0.95 (0.56–1.62)

0.86

ALK

>median (vs. <median)

1.17 (0.72–1.89)

0.52

1.14 (0.68–1.92)

0.61

HGF

>median (vs. <median)

1.29 (0.80–2.09)

0.29

1.34 (0.77–2.33)

0.29

p53

Mutation (vs. wild type)

1.72 (0.98–3.03)

0.059

1.51 (0.82–2.81)

0.19

1.55 (0.88–2.73)

0.13

PIK3CA

Mutation (vs. wild type)

0.40 (0.14–1.10)

0.077

0.28 (0.09–0.90)

0.033

0.34 (0.12–0.96)

0.042

APC

Mutation (vs. wild type)

0.87 (0.40–1.90)

0.72

0.81 (0.23–2.86)

0.74

ERBB4

Mutation (vs. wild type)

0.63 (0.23–1.73)

0.37

0.91 (0.27–3.10)

0.88

FBXW7

Mutation (vs. wild type)

0.56 (0.20–1.54)

0.26

0.43 (0.13–1.44)

0.17

BRAF

Mutation (vs. wild type)

0.99 (0.40–2.47)

0.99

1.83 (0.56–6.04)

0.32

RB1

Mutation (vs. wild type)

1.03 (0.41–2.57)

0.95

1.79 (0.52–6.11)

0.35