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Table 2 Factors associated with overall survival in univariate and multivariate analyses

From: PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue

  Univariate analysis Multivariate analysis (including all variables) Multivariate analysis
Factors Category HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
Age ≥65 (vs. < 65) 1.11 (0.68–1.79) 0.68 1.25 (0.74–2.11) 0.40   
Male Male (vs. Female) 2.36 (0.86–6.49) 0.096 2.48 (0.86–7.20) 0.094 2.30 (0.83–6.36) 0.11
Smoking status 2–3 (vs 0–1) 1.22 (0.71–2.13) 0.47 0.74 (0.40–1.36) 0.33   
cT T3 (vs. T1, T2) 4.25 (1.04–17.41) 0.044 5.23 (1.19–23.00) 0.029 4.30 (1.04–17.70) 0.044
cN N1 (vs. N0) 1.52 (0.84–2.75) 0.16 1.12 (0.57–2.19) 0.75   
NAC Without (vs. with) 1.01 (0.62–1.65) 0.97 0.88 (0.52–1.50) 0.65   
HER2 >median (vs. <median) 0.93 (0.57–1.50) 0.76 0.92 (0.54–1.55) 0.75   
MET >median (vs. <median) 0.75 (0.46–1.21) 0.24 0.74 (0.44–1.27) 0.28   
EGFR >median (vs. <median) 0.99 (0.61–1.60) 0.97 0.95 (0.56–1.62) 0.86   
ALK >median (vs. <median) 1.17 (0.72–1.89) 0.52 1.14 (0.68–1.92) 0.61   
HGF >median (vs. <median) 1.29 (0.80–2.09) 0.29 1.34 (0.77–2.33) 0.29   
p53 Mutation (vs. wild type) 1.72 (0.98–3.03) 0.059 1.51 (0.82–2.81) 0.19 1.55 (0.88–2.73) 0.13
PIK3CA Mutation (vs. wild type) 0.40 (0.14–1.10) 0.077 0.28 (0.09–0.90) 0.033 0.34 (0.12–0.96) 0.042
APC Mutation (vs. wild type) 0.87 (0.40–1.90) 0.72 0.81 (0.23–2.86) 0.74   
ERBB4 Mutation (vs. wild type) 0.63 (0.23–1.73) 0.37 0.91 (0.27–3.10) 0.88   
FBXW7 Mutation (vs. wild type) 0.56 (0.20–1.54) 0.26 0.43 (0.13–1.44) 0.17   
BRAF Mutation (vs. wild type) 0.99 (0.40–2.47) 0.99 1.83 (0.56–6.04) 0.32   
RB1 Mutation (vs. wild type) 1.03 (0.41–2.57) 0.95 1.79 (0.52–6.11) 0.35   
  1. Abbreviations: HR hazard ratio, CI confidence interval, cT clinical T, cN clinical N