Fig. 2

Genome-wide mutational landscape of ESCC identified by whole-exome sequencing (n = 126). a Number of total nonsynonymous mutations in individuals is illustrated in the bar graph. b Left, mutations in a selection of frequently mutated genes, arranged vertically by functional group and colored by the type of gene alteration. Samples are displayed as columns. Right, the percentage of individuals with somatic alterations that targeted each gene. c Smoking status is represented by cumulative exposure doses measured by pack years