Table 4 Multivariate analysis of factors associated with survival
Variables | Parameters | Overall survival | Progression-free survival | ||
|---|---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | ||
Age (year) | <  60 vs. ≥ 60 | – | 0.068 | – | 0.107 |
Tumor location | Glottic vs. Supraglottic | 2.71 (1.26–5.80) | 0.011* | – | 0.445 |
Glottic vs. Subglottic | – | 0.110 | – | 0.440 | |
T classification | T1-T2 vs. T3-T4 | – | 0.135 | – | 0.593 |
N classification | N0 vs. N1-N2 | – | 0.116 | – | 0.240 |
TNM stage | I-II vs. III-IV | 4.24 (2.13–7.79) | < 0.001* | 3.41 (2.25–5.16) | < 0.001* |
Histology | Well-moderate vs. Poor | – | 0.100 | – | 0.181 |
Laryngectomy | Partial vs. Total | – | 0.229 | – | 0.752 |
Medication | No vs. Yes | – | 0.361 | – | 0.850 |
Comorbidities | No vs. Yes | – | 0.552 | – | 0.678 |
Pre NLR | <  2.45 vs. ≥ 2.45 | 1.64 (1.06–2.54) | 0.026* | 1.52 (1.04–2.23) | 0.029* |
Pre PLR | <  114 vs. ≥ 114 | – | 0.765 | – | 0.986 |
Pre MLR | < 0.21 vs. ≥ 0.21 | – | 0.317 | – | 0.567 |
Pre ALP | <  78 vs. ≥ 78 | – | 0.340 | – | 0.271 |
Post NLR | <  2.85 vs. ≥ 2.85 | – | 0.245 | – | 0.701 |
Post PLR | <  111 vs. ≥ 111 | – | 0.584 | – | 0.571 |
Post MLR | < 0.36 vs. ≥ 0.36 | 2.02 (1.29–3.14) | 0.002* | 1.57 (1.05–2.34) | 0.026* |