Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma

Table 2 Univariate analysis of inflammatory markers associated with survival

Variables	Parameters	n	Overall survival (%)					Progression-free survival (%)
Variables	Parameters	n	3-year	5-year	p ^a	HR (95% CI)	p ^b	3-year	5-year	p ^a	HR (95% CI)	p ^b
Overall	–	361	78.9	74.1	–			69.1	65.5	–
Preoperative
NLR	< 2.45	234	85.9	81.8		1		76.4	73.8		1
NLR	≥ 2.45	127	66.1	60.3	< 0.001*	2.53 (1.66–3.84)	< 0.001*	55.6	50.9	< 0.001*	2.13 (1.49–3.07)	< 0.001*
PLR	< 114	253	85.0	78.4		1		73.8	69.3		1
PLR	≥ 114	108	64.8	63.7	0.001*	2.05 (1.35–3.12)	0.001*	58.3	57.0	0.015*	1.58 (1.09–2.29)	0.016*
MLR	< 0.21	191	85.9	81.1		1		75.3	71.3		1
MLR	≥ 0.21	170	71.2	66.2	0.001*	1.99 (1.30–3.06)	0.002*	61.8	58.8	0.010*	1.61 (1.12–2.32)	0.011*
ALP	< 78	196	83.2	78.0		1		74.0	69.6		1
ALP	≥ 78	165	73.9	69.6	0.028*	1.59 (1.05–2.41)	0.030*	63.2	60.8	0.032*	1.48 (1.03–2.13)	0.034*
LDH	< 185	258	79.8	75.6		1		70.2	66.7		1
LDH	≥ 185	103	76.7	70.6	0.275	1.28 (0.82–1.98)	0.278	66.1	64.5	0.451	1.16 (0.79–1.71)	0.453
Postoperative
NLR	< 2.85	231	88.7	82.8		1		77.7	72.9		1
NLR	≥ 2.85	130	61.5	58.6	< 0.001*	3.18 (2.08–4.86)	< 0.001*	53.7	52.5	< 0.001*	2.18 (1.52–3.14)	< 0.001*
PLR	< 111	191	89.5	85.9		1		78.3	72.3		1
PLR	≥ 111	170	67.1	61.0	< 0.001*	3.13 (1.98–4.94)	< 0.001*	58.9	58.0	0.001*	1.85 (1.28–2.68)	0.001*
MLR	< 0.36	280	86.4	80.8		1		75.8	71.8		1
MLR	≥ 0.36	81	53.1	51.3	< 0.001*	3.65 (2.40–5.56)	< 0.001*	45.0	43.2	< 0.001*	2.60 (1.79–3.79)	< 0.001*
ALP	< 84	237	79.7	74.1		1		70.2	65.8		1
ALP	≥ 84	124	77.4	74.7	0.694	1.09 (0.71–1.69)	0.695	67.0	65.5	0.509	1.14 (0.78–1.66)	0.512
LDH	< 158	135	82.2	79.7		1		73.9	69.8		1
LDH	≥ 158	226	77.0	70.8	0.073	1.51 (0.96–2.39)	0.076	66.1	63.0	0.097	1.39 (0.94–2.05)	0.100

Abbreviations: HR hazard ratio, CI confidence interval, NLR neutrophil-lymphocyte ratio, PLR platelet-lymphocyte ratio, MLR monocyte-lymphocyte ratio, ALP alkaline phosphatase, LDH lactate dehydrogenase
^*Statistically significant p < 0.05
^athe p value for log-rank test ^b the p value for HR in Cox analysis

ISSN: 1471-2407