Table 4 Toxicity outcomes in this meta-analysis
Adverse Effects | Number Of Concerning Trials | Pooled RR | 95%CI | P-Value | I2 For Homogeneity | |
|---|---|---|---|---|---|---|
Hematological Toxic Effects | Grade 3–4 Anemia | 9 | 0.76 | 0.54–1.09 | 0.13 | 60% |
Grade 3–4 Leucopenia | 7 | 0.58 | 0.44–0.77 | 0.0002 | 61% | |
Grade 3–4 Neutropenia | 7 | 0.60 | 0.46–0.77 | < 0.0001 | 89% | |
Grade 3–4 Thrombocytopenia | 9 | 0.46 | 0.31–0.70 | 0.0003 | 63% | |
Grade 3–4 Febrile Neutropenia | 6 | 0.64 | 0.42–0.97 | 0.03 | 55% | |
Non-hematological Toxic Effects | Grade 3–4 Diarrhea | 9 | 7.96 | 5.21–12.17 | < 0.00001 | 40% |
Infection | 7 | 0.80 | 0.67–0.95 | 0.01 | 25% | |
Alopecia | 3 | 0.48 | 0.18–1.29 | 0.15 | 88% | |
Fatigue | 4 | 1.18 | 0.98–1.42 | 0.07 | 0% | |
Drug-related Death | 3 | 1.53 | 0.79–2.99 | 0.21 | 0% | |