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Table 2 Quantification of SPLs (VIP > 1) in A549 and A549T

From: LC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain

SPLs

Content (pmol/5*105 cells)

ChangeA549T vs A549

p value

VIP

A549 (n = 20)

A549T (n = 20)

SM (d18:2/20:0)

1.96 ± 0.16

0.53 ± 0.07

< 0.001

1.07408

SM (d18:1/26:1)

19.8 ± 1.22

0.34 ± 0.04

< 0.001

1.08696

SM (d18:1/26:0)

5.67 ± 0.31

0.20 ± 0.02

< 0.001

1.08775

SM (d18:1/25:1)

9.28 ± 0.43

0.45 ± 0.05

< 0.001

1.08860

SM (d18:1/25:0)

4.09 ± 0.23

0.42 ± 0.04

< 0.001

1.08699

SM (d18:1/24:3)

3.34 ± 0.26

0.47 ± 0.07

< 0.001

1.08120

SM (d18:1/24:2)

32.5 ± 1.55

8.99 ± 0.87

< 0.001

1.08501

SM (d18:1/24:1)

542 ± 23.8

37.9 ± 2.59

< 0.001

1.08879

SM (d18:1/24:0)

298 ± 13.0

41.5 ± 3.16

< 0.001

1.08829

SM (d18:1/23:2)

1.12 ± 0.11

0.25 ± 0.04

< 0.001

1.06488

SM (d18:1/23:1)

21.6 ± 1.08

2.58 ± 0.30

< 0.001

1.08745

SM (d18:1/23:0)

26.4 ± 1.26

6.57 ± 0.51

< 0.001

1.08618

SM (d18:1/22:2)

1.25 ± 0.12

0.15 ± 0.02

< 0.001

1.07067

SM (d18:1/22:1)

16.4 ± 0.81

2.07 ± 0.18

< 0.001

1.08760

SM (d18:1/22:0)

142 ± 6.17

26.9 ± 1.78

< 0.001

1.08783

SM (d18:1/21:1)

0.82 ± 0.07

0.15 ± 0.02

< 0.001

1.07308

SM (d18:1/21:0)

4.66 ± 0.25

1.39 ± 0.12

< 0.001

1.08216

SM (d18:1/20:1)

0.87 ± 0.13

0.06 ± 0.00

< 0.001

1.06102

SM (d18:1/20:0)

17.6 ± 0.86

3.08 ± 0.31

< 0.001

1.08689

SM (d18:1/19:0)

1.94 ± 0.20

0.21 ± 0.03

< 0.001

1.07588

SM (d18:1/18:1)

39.0 ± 1.99

8.13 ± 0.58

< 0.001

1.08637

SM (d18:1/18:0)

69.5 ± 2.72

9.07 ± 0.54

< 0.001

1.08896

SM (d18:1/17:0)

14.1 ± 0.72

4.76 ± 0.39

< 0.001

1.08307

SM (d18:1/16:0)

982 ± 38.5

629 ± 23.5

< 0.001

1.06108

SM (d18:1/14:0)

27.3 ± 1.04

17.2 ± 0.65

< 0.001

1.06732

SM (d18:0/24:0)

15.3 ± 0.78

0.11 ± 0.02

< 0.001

1.08843

SM (d18:0/23:0)

2.45 ± 0.15

0.02 ± 0.00

< 0.001

1.08694

SM (d18:0/22:0)

23.3 ± 1.05

0.23 ± 0.04

< 0.001

1.08900

SM (d18:0/20:0)

4.59 ± 0.24

0.08 ± 0.01

< 0.001

1.08808

SM (d18:0/19:0)

0.49 ± 0.07

0.01 ± 0.00

< 0.001

1.05519

SM (d18:0/18:0)

17.0 ± 0.55

0.10 ± 0.03

< 0.001

1.09013

SM (d18:0/17:0)

0.65 ± 0.07

0.06 ± 0.01

< 0.001

1.07030

SM (d18:0/16:0)

545 ± 28.7

12.3 ± 0.94

< 0.001

1.08809

SM (d18:0/15:0)

1.74 ± 0.16

0.10 ± 0.02

< 0.001

1.08041

SM (d18:0/14:0)

5.83 ± 0.40

0.28 ± 0.03

< 0.001

1.08565

Cer (d18:2/24:1)

1.01 ± 0.21

0.03 ± 0.01

< 0.001

1.04397

Cer (d18:1/24:1)

46.1 ± 5.83

3.60 ± 0.44

< 0.001

1.07110

Cer (d18:1/24:0)

42.0 ± 2.08

9.83 ± 0.41

< 0.001

1.08653

Cer (d18:1/23:1)

1.37 ± 0.22

0.06 ± 0.01

< 0.001

1.06057

Cer (d18:1/23:0)

2.54 ± 0.27

0.53 ± 0.09

< 0.001

1.06941

Cer (d18:1/22:1)

1.20 ± 0.27

0.04 ± 0.01

< 0.001

1.03542

Cer (d18:1/22:0)

14.4 ± 0.94

1.90 ± 0.39

< 0.001

1.08443

Cer (d18:1/20:0)

1.69 ± 0.33

0.07 ± 0.02

< 0.001

1.04721

Cer (d18:1/18:1)

20.1 ± 1.33

4.03 ± 0.49

< 0.001

1.08187

Cer (d18:1/18:0)

8.03 ± 0.72

0.26 ± 0.04

< 0.001

1.08142

Cer (d18:1/16:0)

52.0 ± 3.59

10.7 ± 0.98

< 0.001

1.08243

Cer (d18:1/15:0)

3.14 ± 0.46

1.34 ± 0.30

< 0.001

1.00100

Cer (d18:0/24:0)

1.44 ± 0.11

0.34 ± 0.04

< 0.001

1.07587

Cer (d18:0/16:0)

3.46 ± 0.25

0.07 ± 0.01

< 0.001

1.05883

HexCer (d18:1/26:0)

0.41 ± 0.10

0.04 ± 0.02

< 0.001

1.00780

HexCer (d18:1/24:1)

9.25 ± 0.97

0.02 ± 0.00

< 0.001

1.07959

HexCer (d18:1/16:0)

5.06 ± 0.89

21.6 ± 2.10

< 0.001

1.07118

LacCer (d18:1/24:1)

0.22 ± 0.05

19.9 ± 2.17

< 0.001

1.07014

LacCer (d18:1/24:0)

0.37 ± 0.03

56.4 ± 3.16

< 0.001

1.07766

LacCer (d18:1/22:0)

0.06 ± 0.01

21.6 ± 2.85

< 0.001

1.07258

LacCer (d18:1/16:0)

1.15 ± 0.55

115 ± 11.6

< 0.001

1.08013

So (t17:1)

2.21 ± 0.17

0.62 ± 0.08

< 0.001

1.07483