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Fig. 1 | BMC Cancer

Fig. 1

From: Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice

Fig. 1

a Breeding scheme to generate KC;Hsl+/+, KC;Hsl+/−, and KC;Hsl−/− mice. b Exon structure of wildtype and HSL deficient mice. Replacing portions of exon 5 and the entire exon 6 with a neo cassette renders mice functionally HSL deficient [10]. Representative genotyping result showing a single 320 bp band in Hsl−/− mice, a single 269 bp band in Hsl+/+ mice, and a double band (320 bp and 269 bp) in Hsl+/− mice. c Weight curves of female and male KC;Hsl+/+ (n = 9 males+ 14 females), KC;Hsl+/− (n = 20 males+ 23 females), and KC;Hsl−/− (n = 10 males+ 10 females) mice fed standard rodent chow for 20 weeks. d Plasma levels of cholesterol, triglycerides, glucose, insulin, and leptin in KC;Hsl+/+ and KC;Hsl−/− mice at 6 months (at sacrifice). N = 6

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