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Fig. 1 | BMC Cancer

Fig. 1

From: Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment

Fig. 1

Effect of irinotecan treatment on the phosphokinome profile of HCT116 cell xenografts. (a) Tumour growth in nude mice treated with 20 mg/kg irinotecan or vehicle (NT) (n = 6/group). Each growth curve represents the mean of tumor growth volume for mice of the corresponding group. (b) Z-scores of the luminescence values of individual target peptides from PTK and STK PamChip arrays using irinotecan-treated and control samples. (c) List of PTK and STK peptides with a Z score > 1 and the corresponding Z-score value; peptide names are provided according to the UniProt nomenclature. (d) Western blot assay showing the increase of MEK and AKT phosphorylation in tumour samples from xenografted mice treated with irinotecan or vehicle (saline)

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BMC Cancer

ISSN: 1471-2407

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